Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
复制标题
DOI：
10.1093/ofid/ofx255
复制
发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Pirofski, Liise-anne
中科院分区：
文献类型：
--
作者：
Rohatgi, Soma;Nakouzi, Antonio;Pirofski, Liise-anne
抗体免疫在预防新型隐球菌方面的重要性仍未得到解决。我们检测了12例隐球菌病患者和21例对照者的血清新型隐球菌特异性抗体和总抗体水平以及外周血B细胞亚群。在调整年龄、性别和种族后，隐球菌荚膜多糖免疫球蛋白G在病例组高于对照组，而总B和记忆B细胞水平较低。这些关联与人类免疫缺陷病毒相关隐球菌病患者的既往研究结果相似，并提示B细胞亚群紊乱也可能与既往正常隐球菌病患者的疾病相关。
The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.