The Platelet Response to Tissue Injury.
The Platelet Response to Tissue Injury.
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DOI：
10.3389/fmed.2018.00317
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发表时间：
2018
影响因子：
3.9
通讯作者：
Langer HF
中科院分区：
文献类型：
--
作者：
Eisinger F;Patzelt J;Langer HF
近年来，各种研究越来越多地解释血小板功能，不仅在其作为细胞止血和凝血调节剂的中心作用。事实上，越来越多的证据表明，在特定条件下，血小板作为血管系统，止血和免疫系统之间的介质。因此，它们在损伤或炎症反应后参与组织重塑和组织重组的许多过程中是必不可少的。这些过程包括促进炎症过程、在细菌和病毒感染期间对先天和适应性免疫反应的贡献、血管生成的调节以及稳态组织稳态或组织分解后细胞凋亡的调节。总而言之，血小板对组织稳态的控制可能比通常认为的要大得多。本文综述了血小板作为组织重塑网络的一部分，目前的知识，并试图提供可能的临床治疗的翻译影响。
In recent years, various studies have increasingly explained platelet functions not only in their central role as a regulator in cellular hemostasis and coagulation. In fact, there is growing evidence that under specific conditions, platelets act as a mediator between the vascular system, hemostasis, and the immune system. Therefore, they are essential in many processes involved in tissue remodeling and tissue reorganization after injury or inflammatory responses. These processes include the promotion of inflammatory processes, the contribution to innate and adaptive immune responses during bacterial and viral infections, the modulation of angiogenesis, and the regulation of cell apoptosis in steady-state tissue homeostasis or after tissue breakdown. All in all platelets may contribute to the control of tissue homeostasis much more than generally assumed. This review summarizes the current knowledge of platelets as part of the tissue remodeling network and seeks to provide possible translational implications for clinical therapy.