Frequent detection of worm movements in onchocercal nodules by ultrasonography.
Frequent detection of worm movements in onchocercal nodules by ultrasonography.
复制标题
通过超声检查经常检测到Onchocercal结节中的蠕虫运动。
DOI：
10.1186/1475-2883-4-1
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发表时间：
2005-03-23
期刊：
影响因子：
--
通讯作者：
Hoerauf A
中科院分区：
文献类型：
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作者：
Mand S;Marfo-Debrekyei Y;Debrah A;Buettner M;Batsa L;Pfarr K;Adjei O;Hoerauf A
超声检查（USG）是一种诊断淋巴丝虫病的合适工具，因为感染男性阴囊淋巴管中的班氏丝虫成虫可以通过特征性运动模式（丝虫舞蹈征）检测到。在盘尾丝虫病中，USG尚未证实蠕虫的移动。此外，由于缺乏纵向观察体内潜在杀微丝蚴药物诱导的变化的工具，因此在试验中验证药物对活的旋绕盘尾丝虫成虫的影响受到阻碍。本研究测定了广东省USG引起的肠扭转。在加纳的盘尾丝虫病流行区，通过触诊招募了61名感染盘尾丝虫病的患者，并使用配备7.5 - 10 MHz线性换能器的超声系统通过USG检查了盘尾丝虫瘤。盘尾丝虫被记录在录像带上，并就位置、数量和大小以及成虫丝虫的移动进行评价。61例患者中，触诊发现303例，超声检查发现401例。61例患者中18例（29.5%）共22个结节伴运动成人O形结节。检测到丝虫扭转并以动画超声图像作为MP-4视频呈现。超声检查的盘尾丝虫瘤，活的成年丝虫可以显示可以作为一个新的工具，在体内的纵向观察接受治疗的盘尾丝虫病患者，并作为一个辅助组织学评价。
Ultrasonography (USG) is known to be a suitable tool for diagnosis in lymphatic filariasis as the adult filarial nematode Wuchereria bancrofti in scrotal lymphatic vessels of infected men can be detected by the characteristic pattern of movement, the Filaria Dance Sign. In onchocerciasis, moving adult worms have not yet been demonstrated by USG. In addition the verification of drug effects on living adult Onchocerca volvulus filariae in trials is hampered by the lack of tools for longitudinal observation of alterations induced by potentially macrofilaricidal drugs in vivo. The present study was carried out to determine the frequency of detection of moving adult filariae of O. volvulus by USG. In an endemic region for onchocerciasis in Ghana, 61 patients infected with onchocerciasis were recruited by palpation and onchocercomas examined by USG using an ultrasound system equipped with a 7.5 – 10 MHz linear transducer. Onchocercomas were recorded on videotape and evaluated with regard to location, number and size, as well as to movements of adult filariae. In the 61 patients 303 onchocercomas were found by palpation and 401 onchocercomas were detected by USG. In 18 out of 61 patients (29.5%), altogether 22 nodules with moving adult O. volvulus filariae were detected and are presented in animated ultrasound images as mp-4 videos. Ultrasonographical examinations of onchocercomas where living adult filariae can be displayed may serve as a new tool for the longitudinal observation in vivo of patients with onchocerciasis undergoing treatment and as an adjunct to histological evaluation.