Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study.
Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study.
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DOI：
10.3390/brainsci12060733
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发表时间：
2022-06-02
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
同侧、对侧和双侧重复经颅磁刺激（rTMS）治疗耳鸣的相对益处尚不清楚，尤其是对于单侧耳鸣患者。在这项研究中，我们比较了两周内在110%的静息运动阈值下进行10次1 Hz rTMS后的结果。总共有104例右利手单侧主观性耳鸣患者根据rTMS治疗随机分为四组：左侧（n = 29），右侧（n = 23），双侧（n = 30）和假刺激（n = 22）。结果包括耳鸣的严重程度，心理状态和心理声学措施的估计。左侧或右侧耳鸣患者在治疗组间的分布相似。右侧或假手术治疗组的结局指标无显著变化。左侧组和双侧组治疗后耳鸣严重程度显著降低（p < 0.05）。左侧组同侧治疗的耳鸣严重程度降低幅度最大。左侧组的总体缓解率为56.1%，双侧组为46.7%，右侧组为8.3%，假手术组为8.3%。对于左侧和双侧组，左侧耳鸣患者的应答率大于右侧耳鸣患者。耳鸣严重程度的变化最好通过焦虑、抑郁和耳鸣响度的变化来预测。结果表明，左侧颞顶皮层的rTMS对左侧耳鸣患者比右侧耳鸣患者更有效。
The relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor threshold over a two-week period. In total, 104 right-handed patients with lateralized subjective tinnitus were randomly divided into four groups according to rTMS treatment: Left (n = 29), Right (n = 23), Bilateral (n = 30), and Sham stimulation (n = 22). Outcomes included estimates of tinnitus severity, psychological state, and psychoacoustic measures. Patients with left- or right-sided tinnitus were similarly distributed across treatment groups. There were no significant changes in outcome measures for the Right or Sham treatment groups. For the Left and Bilateral groups, tinnitus severity was significantly lower after treatment (p < 0.05). The reduction in tinnitus severity was largest for ipsilateral treatment in the Left group. The overall response rate was 56.1% for the Left group, 46.7% for the Bilateral group, 8.3% for the Right group, and 8.3% for the Sham group. For the Left and Bilateral groups, the response rate was larger for patients with left- than right-sided tinnitus. Changes in tinnitus severity were best predicted by changes in anxiety, depression, and the loudness of the tinnitus. The results suggests that rTMS on the left temporoparietal cortex is more effective for patients with left-sided than with right-sided tinnitus.
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