Ultraviolet Corneal Crosslinking
Ultraviolet Corneal Crosslinking
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紫外线角膜交联
DOI：
10.15690/vramn562
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Э. Л. Усубов
中科院分区：
文献类型：
--
作者：
М. М. Бикбов;Азат Рашидович Халимов;Э. Л. Усубов
本文综述了紫外线角膜交联的基本信息。该方法广泛用于眼科治疗各种类型的扩张，其特征在于角膜的进行性退行性变化，与其变薄、模糊和瘢痕形成相关，这导致视力显著降低。交联是基于在核黄素存在下角膜波长370 nm的紫外线（UV）照射，导致光化学角膜内相互作用。由于胶原蛋白治疗的交联，角膜的强度和机械性能的增加，阻止了疾病的进展。本文介绍了核黄素-UV-A诱导角膜交联的方法发展的步骤和实施的途径，特别是发生的生物力学、生物化学、形态学和超微结构的变化，以及临床应用的主要领域。
This review presents basic information on UV corneal crosslinking. The method is widely used in ophthalmology to treat various types of ectasia, which are characterized by progressive degenerative changes in the cornea, associated with its thinning , hazing and scarring, which leads to a significant reduction in visual acuity. Crosslinking is based on ultraviolet (UV) irradiation of the cornea wavelength 370 nm in the presence of riboflavin, leading to photochemical i ntracorneal interactions. As a result of crosslinking of collagen treatments, an increase of strength and mechanical properties of the cornea, stops the progression of the disease. The article displays the steps of the method development and the ways of its implementation are described especially occurring biomechanical, biochemical, morphological and ultrastructural changes, as well as the main areas of clinical application of riboflavin-UV-A-induced crosslinking of cornea.