Evaluation of Latent Fingerprints for Drug Screening in a Social Care Setting.
Evaluation of Latent Fingerprints for Drug Screening in a Social Care Setting.
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社会护理环境中药物筛选潜指纹的评估。
DOI：
10.1093/jat/bkaa183
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发表时间：
2022
影响因子：
2.5
通讯作者：
Pollard C
中科院分区：
文献类型：
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作者：
Pollard C
通过潜在指纹（LFP）沉积的汗液以前用于通过即时检测（POCT）检测可卡因，阿片类药物，大麻和安非他明。这种筛查方法将非侵入性采样与快速结果转换相结合，以在实验室外产生定性结果。我们报告了新的应用LFP药物筛选试验在社会关怀设置。使用POCT DOA 114（智能指纹识别有限公司）药物筛查盒对客户进行了随机或常规测试。苯甲酰芽子碱（BZE）、吗啡和苯丙胺分析物的筛选截止值分别为45、35和95 pg/指纹。使用超高效液相色谱串联质谱法分析确认LFP样品（DOA 150，Intelligent Fingerprinting Ltd）和口服液（OF）。36名年龄为36 ± 11岁的客户参与了研究（53%为女性）。个人自我报告饮酒（39%）和吸烟（60%）。在8周内收集的131次筛查测试中，14%的可卡因检测呈阳性，2%的阿片类药物检测呈阳性，1%的苯丙胺检测呈阳性。10%的测试表明使用多种药物。在32个LFP确认测试中，63%的可卡因和BZE呈阳性。还检测到类阿片（31%），其中代谢物6-单乙酰吗啡（6-MAM）最常见（16%）。在OF中，可卡因是主要分析物（9%），其次是6-MAM（5%）。在比较阳性LFP筛查试验与阳性OF样本，我们发现39%和38%的可卡因和阿片类药物阳性，分别。在通过LFP POCT筛选的药物中，可卡因是LFP和OF确认样本中最常见的分析物。该研究是社会护理环境中常规药物筛查程序的一个步骤，特别适用于正在监测药物使用的客户的现场可卡因检测。此外，测试很容易被客户和社会护理工作者接受。
Sweat deposited via latent fingerprints (LFPs) was previously used to detect cocaine, opioids, cannabis and amphetamine via a point-of-care test (POCT). This screening method combined non-invasive sampling with a rapid result turnaround to produce a qualitative result outside of the laboratory. We report the novel application of a LFP drug screening test in a social care setting. Clients were tested on either anad hocor a routine basis using the POCT DOA114 (Intelligent Fingerprinting Ltd) drug screening cartridge. Screening cutoff values were 45, 35 and 95 pg/fingerprint for benzoylecgonine (BZE), morphine and amphetamine analytes, respectively. Confirmation LFP samples (DOA150, Intelligent Fingerprinting Ltd) and oral fluid (OF) were analyzed using ultra-performance liquid chromatography with tandem mass spectrometry. Thirty-six clients aged 36 ± 11 years participated (53% females). Individuals self-reported alcohol consumption (39%) and smoking (60%). Of 131 screening tests collected over 8 weeks, 14% tested positive for cocaine, 2% tested positive for opioids and 1% tested positive for amphetamine. Polydrug use was indicated in 10% of tests. Of 32 LFP confirmation tests, 63% were positive for cocaine and BZE. Opioids were also detected (31%), with the metabolite 6-monoacetylmorphine (6-MAM) being the most common (16%). In OF, cocaine was the dominant analyte (9%) followed by 6-MAM (5%). On comparing positive LFP screening tests with positive OF samples, we found that 39% and 38% were cocaine and opiate positive, respectively. Of the drugs screened for via the LFP POCT, cocaine was the most prevalent analyte in LFP and OF confirmation samples. The study is a step change in the routine drug screening procedures in a social care setting, especially useful for on-site cocaine detection in clients whose drug use was being monitored. Additionally, testing was easily accepted by clients and social care workers.