Co-morbid association of depression and COPD: A population-based study
Co-morbid association of depression and COPD: A population-based study
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DOI：
10.1016/j.rmed.2008.12.010
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发表时间：
2009-06-01
影响因子：
4.3
通讯作者：
Tan, Wan-Cheng
中科院分区：
文献类型：
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作者：
Ng, Tze-Pin;Niti, Mathew;Tan, Wan-Cheng
目的：抑郁症在 COPD 患者中常见，但抑郁症与 COPD 的独立关联以及抑郁症对 COPD 结局的影响尚不明确。 方法：对 2402 名年龄 >= 55 岁的患有或不患有 COPD 的中国人群样本（慢性咳嗽、咳痰或呼吸困难和气流阻塞以及 FEV1/FVC < 0.70 的特征症状）进行老年抑郁量表（评分 >= 5）评估，依赖于基本症状日常生活活动（ADL）、SF-12健康状况、吸烟和药物行为。结果：189名患有慢性阻塞性肺病的受访者的抑郁症状患病率（22.8%）高于2213名没有慢性阻塞性肺病的受访者（12.4%）；多变量奇数比 (OR) 为 1.86；控制混杂风险因素后，95% CI 为 1.25-2.75。在对 COPD 受访者的多变量分析中，与那些没有抑郁的人 (N = 146) 相比，那些患有抑郁症的人 (N = 43) 更有可能报告 ADL 障碍 (OR = 2.89，p = 0.049)、较差或一般的自报告健康状况 (OR = 3.35，p = 0.004)、较差的 SF-12 PCS 分数 (OR = 2.35，p = 0.049)、较差的 SF-12 PCS 分数 (OR = 2.35，p = 0.041）和 SF-12 MCS 分数（OR = 4.17，p
Objectives: Depression occurs commonly among patients with COPD, but the independent association of depression and COPD and the effect of depression on COPD outcomes are not welt established.Method: A population sample of 2402 Chinese aged >= 55 with and without COPD (characteristic symptoms of chronic cough, sputum or breathlessness and airflow obstruction and FEV1/FVC < 0.70) was assessed on Geriatric Depression Scale (score >= 5), dependence on basic activities of daily living (ADL), SF-12 health status, smoking and medication behaviour.Results: The 189 respondents with COPD showed higher depressive symptoms prevalence (22.8%) than 2213 respondents without COPD (12.4%); multivariate odd ratio (OR) was 1.86; 95% CI, 1.25-2.75 after controlling for confounding risk factors. In multivariate analyses of respondents with COPD, those who were depressed (N = 43), compared to those who were not (N = 146), were more likely to report ADL disability (OR = 2.89, p = 0.049) poor or fair setf-reported health (OR = 3.35, p = 0.004), poor SF-12 PCS scores (OR = 2.35, p = 0.041) and SF-12 MCS scores (OR = 4.17, p