Feasibility evaluation of transtympanic laser stimulation of the cochlea from the outer ear
Feasibility evaluation of transtympanic laser stimulation of the cochlea from the outer ear
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DOI：
10.1101/2021.11.08.467672
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Miku Uenaka;Hidekazu Nagamura;S. Hiryu;Kohta I. Kobayasi;Yuta Tamai
中科院分区：
文献类型：
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作者：
Miku Uenaka;Hidekazu Nagamura;S. Hiryu;Kohta I. Kobayasi;Yuta Tamai
红外激光刺激已被研究作为听觉假体的替代方法。本研究评估了从外耳绕过中耳功能对耳蜗进行红外激光刺激的可行性。将光纤插入长爪沙鼠耳道，用激光经鼓膜照射耳蜗。向动物提供脉冲红外激光（10.1 mJ/cm 2）和咔哒声（70峰-峰等效声压级）。在鼓膜和耳蜗之间插入滤波器后，激光诱发的耳蜗反应幅度系统性降低;然而，听觉诱发的耳蜗反应并没有降低。移除滤波器，激光诱发反应恢复到原始水平左右。随着红外滤光片吸光度的增加，滤光片插入前和插入过程中的振幅比和响应振幅的相对变化显着降低。这些结果表明，激光照射可以绕过中耳功能，直接激活耳蜗。因此，基于激光刺激的听觉假体代表了需要外科植入物的传统听觉假体的可能的非侵入性替代方案。
Infrared laser stimulation has been studied as an alternative approach to auditory prostheses. This study evaluated the feasibility of infrared laser stimulation of the cochlea from the outer ear bypassing the middle ear function. An optic fiber was inserted into the ear canal and a laser was used to irradiate the cochlea through the tympanic membrane in Mongolian gerbil. A pulsed infrared laser (10.1 mJ/cm2) and clicking sound (70 peak-to-peak equivalent sound pressure level) were presented to the animals. The amplitude of the laser-evoked cochlear response was systematically decreased following insertion of a filter between the tympanic membrane and cochlea; however, the auditory-evoked cochlear response did not decrease. The filter was removed and the laser-evoked response returned to around the original level. The amplitude ratio and the relative change in response amplitude before and during filter insertion significantly decreased as the absorbance of the infrared filter increased. These results indicate that laser irradiation could bypass the function of the middle ear and directly activate the cochlea. Therefore, an auditory prosthesis based on laser stimulation represents a possible noninvasive alternative to conventional auditory prostheses requiring surgical implants.