Polymorphism of the β3-Adrenergic Receptor Gene Affects Basal Metabolic Rate in Obese Finns
Polymorphism of the β3-Adrenergic Receptor Gene Affects Basal Metabolic Rate in Obese Finns
复制标题
β3-肾上腺素受体基因多态性影响肥胖芬兰人的基础代谢率
作者：
Raisa Sipilä;M. Uusitupa;S. Heikkinen;A. Rissanen;M. Laakso
低基础代谢率（BMR）是体重增加和肥胖的危险因素。β3-肾上腺素能受体基因第64位密码子多态性与BMR相关。我们研究了肥胖芬兰人β3-肾上腺素能受体基因Trp 64 Arg的频率以及该多态性对BMR的影响。总共有170名肥胖受试者（29名男性，141名女性，BMI 34.7 ± 3.8 kg/m2，平均值± SD）参加了研究。Trp 64 Arg多态性频率为19%。没有一个肥胖的受试者是纯合子的精氨酸编码等位基因。肥胖芬兰人Trp 64 Arg多态性的频率与非肥胖和血糖正常对照组无差异。Trp 64 Arg多态性受试者（n = 20）的BMR经瘦体重和年龄校正后低于正常纯合子Trp 64 Trp（n = 99）（1，569 ± 73 vs. 1，635 ± 142 kcal/d，P = 0.004）。对于女性组（n = 98），相应值分别为1，501 ± 66 kcal/天vs. 1，568 ± 127 kcal/天（P = 0.004）。Trp 64 Arg多态性组与非Trp 64 Arg多态性组之间的体重、BMI、腰臀比、瘦体重、脂肪百分比和呼吸商无显著差异。两组之间的血糖和胰岛素水平均无差异。我们的结论是β3-肾上腺素能受体基因的Trp 64 Arg多态性影响肥胖芬兰人的基础代谢率，但对葡萄糖代谢没有显著影响。
Low basal metabolic rate (BMR) is a risk factor for weight gain and obesity. The polymorphism at codon 64 of the β3-adrenergic receptor gene has been suggested to be associated with BMR. We investigated the frequency of the Trp64Arg of the β3-adrenergic receptor gene and the effects of this polymorphism on BMR in obese Finns. Altogether, 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, mean ± SD) participated in the study. The frequency of the Trp64Arg polymorphism was 19%. None of the obese subjects were homozygous for the Arg-encoding allele. The frequency of the Trp64Arg polymorphism in obese Finns did not differ from nonobese and normoglycemic control subjects. BMR adjusted for lean body mass and age was lower in subjects with the Trp64Arg polymorphism (n = 20) than in normal homozygotes Trp64Trp (n = 99) (1,569 ± 73 vs. 1,635 ± 142 kcal/day, P = 0.004). For the female group (n = 98), the respective values were 1,501 ± 66 kcal/day vs. 1,568 ± 127 kcal/day (P = 0.004). There were no significant differences in weight, BMI, waist-tohip ratio, lean body mass, percentage of fat, and respiratory quotient between the groups with or without the Trp64Arg polymorphism. Neither serum glucose nor insulin levels differed between the two groups. We conclude that the Trp64Arg polymorphism of the β3-adrenergic receptor gene affects basal metabolic rate in obese Finns but does not have significant effect on glucose metabolism.
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR