Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines
Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines
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DOI：
10.1016/j.cellimm.2017.10.009
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发表时间：
2018-01-01
影响因子：
4.3
通讯作者：
Kobata, Tetsuji
中科院分区：
文献类型：
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作者：
Hashiguchi, Masaaki;Kashiwakura, Yuji;Kobata, Tetsuji
肠道免疫球蛋白(IGs)可保护肠道免受微生物侵袭。然而，对肠道免疫球蛋白产生的调节知之甚少。在本研究中，我们研究了APRIL(肿瘤坏死因子超家族成员[TNFSF]13)和BAFF(TNFSF13B)在肠道免疫球蛋白诱导中的作用。Peyer‘s斑块(PPS)至少部分是包括IgA在内的免疫球蛋白的诱导部位。体内引入APRIL和BAFF可降低PPS中IgG1(+)或IgG2b(+)B细胞的比例。给予TACI-Fc可上调PPS中IgG1(+)、IgG2b(+)和IgA(+)B细胞的频率，提示APRIL和BAFF抑制了这些区域的Ig产生。Taci-Fc还可上调PPS的肠道IgA水平，扩大生发中心B细胞。这些结果表明，APRIL和BAFF自相矛盾地下调肠道内稳态Ig的产生。
Intestinal immunoglobulins (Igs) protect against microbes. However, the regulation of intestinal Ig production is poorly understood. In this study, we have investigated the roles of APRIL (tumor necrosis factor superfamily member [TNFSF] 13) and BAFF (TNFSF13B) in intestinal Ig induction. Peyer's patches (PPs) are, at least in part, an inductive site for Igs, including IgA. Introducing APRIL and BAFF in vivo lowered the frequency of IgG1(+) or IgG2b(+) B cells in PPs. Administration of TACI-Fc upregulated the frequency of IgG1(+), IgG2b(+), and IgA(+) B cells in PPs, suggesting that APRIL and BAFF attenuate Ig production in these regions. TACI-Fc also upregulated intestinal IgA levels and expanded germinal center B cells in PPs. These results indicate that APRIL and BAFF paradoxically downregulate homeostatic Ig production in the intestines.