Public Health Service study of Reye's syndrome and medications. Report of the main study.
Public Health Service study of Reye's syndrome and medications. Report of the main study.
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公共卫生服务对雷氏综合症和药物的研究。
DOI：
10.1001/jama.1987.03390140075030
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
W. Dowdle
中科院分区：
文献类型：
--
作者：
E. Hurwitz;M. Barrett;D. Bregman;W. Gunn;P. Pinsky;L. Schonberger;J. S. Drage;R. Kaslow;D. Burlington;G. Quinnan,;J. Lamontagne;W. Fairweather;D. Dayton;W. Dowdle
1985年1月至1986年5月，在完成一项试点研究后，进行了一项关于瑞氏综合征与水杨酸盐之间可能相关性的主要研究。27例II期或更深的雷氏综合征患者，其诊断由专家小组确认，并且在雷氏综合征发作前有适当的前驱疾病（水痘，呼吸道疾病或胃肠道疾病），与140名年龄，种族（黑人或非黑人），以及前驱疾病的类型和发作时间相匹配的对照组进行比较。对照组是从同一家医院，急诊室，或学校作为病例患者或通过随机数字电话拨号识别。在初步研究中，观察到在前驱疾病期间和雷氏综合征发作之前摄入水杨酸盐与统计学显著相关（比值比，40; 95%置信下限，5.8）。阿司匹林和非阿司匹林水杨酸盐的独立风险分析显示与阿司匹林显著相关（比值比，26; 95%置信下限，6.4）;非阿司匹林水杨酸盐的独立风险无法评估，因为只有2例未暴露于阿司匹林。对流行病学问题的评估，包括前驱疾病严重程度的病例对照差异，并不能解释观察到的高比值比。在本研究和既往研究中，暴露于水杨酸盐的雷氏综合征患者比例较高（大于或等于90%），这表明，尽管近年来报告的雷氏综合征发病率有所下降，但伴随着儿童中水杨酸盐使用的减少，大多数雷氏综合征病例可能归因于水杨酸盐的使用。
Between January 1985 and May 1986, following completion of a pilot study, a main study concerning the possible association between Reye's syndrome and salicylates was conducted. Twenty-seven patients with stage II or deeper Reye's syndrome whose diagnoses were confirmed by an expert panel and who had appropriate antecedent illnesses (chickenpox, respiratory illness, or gastrointestinal illness) prior to the onset of Reye's syndrome were compared with 140 controls matched for age, race (black or not black), and type and timing of onset of antecedent illness. Controls were selected from the same hospital, emergency room, or school as case-patients or were identified by random-digit telephone dialing. As in the pilot study, a strong statistical association with ingestion of salicylates during the antecedent illness and prior to the onset of Reye's syndrome was observed (odds ratio, 40; lower 95% confidence limit, 5.8). Analysis of the independent risk of aspirin and nonaspirin salicylates revealed a significant association with aspirin (odds ratio, 26; lower 95% confidence limit, 6.4); the independent risk of nonaspirin salicylates could not be assessed because only two cases were not exposed to aspirin. Assessment of epidemiologic issues of concern, including case-control differences in the severity of the antecedent illness, did not explain the high odds ratios that were observed. The high percentage of patients with Reye's syndrome exposed to salicylates (greater than or equal to 90%) in this and prior studies suggests that, though the reported incidence of Reye's syndrome has declined in recent years, concomitant with a decline in salicylate use among children, a majority of Reye's syndrome cases may be attributable to salicylate use.
1979 年至 1984 年，密歇根州雷氏综合征和阿司匹林使用量呈下降趋势。
影响因子：
8
作者：
Remington,PL;Rowley,D;McGee,H;Hall,WN;Monto,AS
通讯作者：
Monto,AS
阿司匹林是雷氏综合症的危险因素。
DOI：
--
发表时间：
1982
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Waldman,RJ;Hall,WN;McGee,H;VanAmburg,G
通讯作者：
VanAmburg,G