Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease
Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease
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DOI：
10.2147/opth.s215322
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发表时间：
2019-01-01
影响因子：
2.2
通讯作者：
Miller, John B.
中科院分区：
文献类型：
--
作者：
Lu, Yifan;Wang, Jay;Miller, John B.
目的：光学相干断层扫描血管造影术（OCT-A）已成为一种新的工具，非侵入性成像和评价视网膜微血管。现有文献很少比较脉络膜视网膜疾病中不同OCT-A器械的OCT-A微血管指标。在此，我们检查了三个可用的OCT-A platforms.Patients和方法的这些指标：所有受试者进行扫描的三个OCT-A设备：Optovue Avanti Angiovue，Topcon DRI-OCT Triton扫描源OCT，和蔡司Cirrus 5000-HD-OCT Angioplex。两名研究者独立测量中心凹无血管区（FAZ）面积。用ImageJ软件从二值化图像计算浅表毛细血管丛（SCP）和深毛细血管丛（DCP）血管密度（VD）。对不同器械的图像质量进行了定性比较。采用组间相关系数（ICC）、BlandAltman分析、重复测量方差分析、事后检验等方法进行统计学分析。FAZ测量的ICC为0.95。三种器械的FAZ面积无显著差异（p= 0.792）。OCT-A器械之间的SCP VD存在显著差异（Triton 0.344 +/- 0.013，Angiovue 0.323 +/- 0.013，Angioplex 0.367 +/- 0.014，p < 0.05）。与Triton（0.331 +/- 0.009）和Angiovue（0.341 +/-0.020）相比，Angioplex（0.385 +/-0.010）观察到的DCP VD显著更大。图像质量的比较显示，Angiovue提供了最高的质量，其次是Angioplex和Triton.Conclusion：核心黄斑微血管指标，现在很容易访问各种可用的OCT-A设备。虽然本研究中所有三种器械的FAZ均可可靠测量，但SCP和DCP的血管密度存在显著差异。因此，临床医生在多中心研究调查和临床试验中使用患者数据时，在比较不同器械的微血管指标时应谨慎。
Purpose: Optical coherence tomography angiography (OCT-A) has emerged as a novel tool for the non-invasive imaging and evaluation of the retinal microvasculature. There is little existing literature that compares OCT-A microvasculature metrics across different OCT-A devices in chorioretinal diseases. Herein, we examined these metrics on three available OCT-A platforms.Patients and methods: All subjects were scanned on each of three OCT-A devices: Optovue Avanti Angiovue, Topcon DRI-OCT Triton Swept-Source OCT, and Zeiss Cirrus 5000-HD-OCT Angioplex. Two investigators independently measured foveal avascular zone (FAZ) area. Superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel densities (VD) were calculated from binarized images with ImageJ software. Image quality across devices was qualitatively compared. Interclass correlation coefficient (ICC), BlandAltman analysis, repeated measures ANOVA, and post-hoc tests were performed for statistical analysis.Results: Thirteen eyes of seven patients with chorioretinal diagnoses were reviewed. ICC for FAZ measurement was 0.95. There was no significant difference in FAZ area across the three devices (p= 0.792). There was a significant difference in the SCP VD between the OCT-A devices (Triton 0.344 +/- 0.013, Angiovue 0.323 +/- 0.013, Angioplex 0.367 +/- 0.014, p < 0.05). Significantly greater DCP VD was observed with Angioplex (0.385 +/- 0.010) in comparison to both Triton (0.331 +/- 0.009) and Angiovue (0.341 +/- 0.020). A comparison of image quality revealed that Angiovue gives the highest quality, followed by Angioplex and Triton.Conclusion: Core macular microvasculature metrics are now readily accessible on a variety of available OCT-A devices. While the FAZ can be reliably measured across all three devices in this study, there were significant differences for the vessel density in both the SCP and DCP. As a result, clinicians should be careful when comparing microvasculature metrics across different devices when using patient data in multicenter research investigations and clinical trials.