Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals.
Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals.
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DOI：
10.1364/oe.20.004159
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发表时间：
2012-02-13
期刊：
影响因子：
3.8
通讯作者：
Esenaliev RO
中科院分区：
文献类型：
--
作者：
Petrov IY;Petrov Y;Prough DS;Cicenaite I;Deyo DJ;Esenaliev RO
脑静脉血氧合的监测（目前是侵入性的）是避免缺氧诱导的脑损伤导致死亡或严重残疾的关键。脑静脉血氧的无创光声监测可能取代现有的有创方法。据我们所知，我们报告的第一次无创监测脑静脉血氧通过完整的头皮，验证了有创，“金标准”的测量。我们在羊上级矢状窦（SSS），一个大的中线脑静脉，使用我们的新的，多波长光声系统进行了体内研究。研究结果表明：1）羊上矢状窦的光声信号可以透过厚而完整的头皮和颅骨检测到，2）上矢状窦信号的幅度与波长和实际上矢状窦血氧含量有很好的相关性，这些血氧含量是通过上矢状窦插管、采血和“金标准”CO-血氧仪测量的; 3）光声预测的氧合与用CO-血氧计测量的氧合强烈相关。我们的研究结果表明，监测脑静脉血氧可以进行无创和准确地通过完整的头皮使用光声系统，因为绵羊头皮和颅骨厚度是人类相媲美，而羊SSS比人类小得多。
Monitoring (currently invasive) of cerebral venous blood oxygenation is a key to avoiding hypoxia-induced brain injury resulting in death or severe disability. Noninvasive, optoacoustic monitoring of cerebral venous blood oxygenation can potentially replace existing invasive methods. To the best of our knowledge, we report for the first time noninvasive monitoring of cerebral venous blood oxygenation through intact scalp that was validated with invasive, “gold standard” measurements. We performed an in vivo study in the sheep superior sagittal sinus (SSS), a large midline cerebral vein, using our novel, multi-wavelength optoacoustic system. The study results demonstrated that: 1) the optoacoustic signal from the sheep SSS is detectable through the thick, intact scalp and skull; 2) the SSS signal amplitude correlated well with wavelength and actual SSS blood oxygenation measured invasively using SSS catheterization, blood sampling, and measurement with “gold standard” CO-Oximeter; 3) the optoacoustically predicted oxygenation strongly correlated with that measured with the CO-Oximeter. Our results indicate that monitoring of cerebral venous blood oxygenation may be performed in humans noninvasively and accurately through the intact scalp using optoacoustic systems because the sheep scalp and skull thickness is comparable to that of humans whereas the sheep SSS is much smaller than that of humans.