N-acetylaspartate concentrations in the thalami of neuropathic pain patients and healthy comparison subjects measured with 1H-MRS
N-acetylaspartate concentrations in the thalami of neuropathic pain patients and healthy comparison subjects measured with 1H-MRS
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DOI：
10.1016/j.mri.2005.10.021
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Nosaka, S
中科院分区：
文献类型：
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作者：
Fukui, S;Matsuno, M;Nosaka, S
应用质子磁共振波谱（H-1-MRS）技术，对神经病理性疼痛患者和健康对照者丘脑中N-乙酰天门冬氨酸（NAA）的绝对浓度进行了研究。对9例神经病理性疼痛患者和14例健康对照者的双侧丘脑体素进行了T MR扫描，采用线性组合法测定了NAA的绝对浓度模型与健康对照组的平均NAA浓度相比，7例患者的对侧丘脑中的NAA浓度显著降低，2例患者的同侧丘脑中的NAA浓度显著降低。两名对标准疼痛治疗无反应的患者的NAA浓度极低。我们的结果表明，使用H-1-MRS神经病理性疼痛似乎与丘脑的神经活动的异常平衡。丘脑中NAA的浓度可能与治疗效果有关。1H-MRS可作为一种有用的非侵入性工具，用于评估丘脑神经活动的神经病理性疼痛患者。(c)2006年爱思唯尔公司All rights reserved.
We investigated the absolute concentration of N-acetylaspartate (NAA) in the thalami of neuropathic pain patients and healthy comparison subjects by single-voxel proton magnetic resonance spectroscopy (H-1-MRS).H-1-MRS was performed with a 1.5-T MR system on a voxel in the thalamus bilaterally in 9 neuropathic pain patients and 14 healthy control subjects.We measured the absolute concentration of NAA using a linear combination model. The NAA concentration in the thalamus decreased significantly on the contralateral side in seven patients and on the ipsilateral side in two patients, as compared with the mean NAA concentration of the healthy control subjects. The NAA concentrations in two patients who did not respond to standard pain treatments were extremely decreased. Our results using H-1-MRS suggest that neuropathic pain seems to be associated with an abnormal balance of the neural activity in the thalamus. The NAA concentration of the thalamus may be related to the efficacy of therapy. 1H-MRS may serve as a useful noninvasive tool for evaluating thalamic neural activity in neuropathic, pain patients. (c) 2006 Elsevier Inc. All rights reserved.