MOSAIC AND POLYMORPHIC IMPRINTING OF THE WT1 GENE IN HUMANS
MOSAIC AND POLYMORPHIC IMPRINTING OF THE WT1 GENE IN HUMANS
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DOI：
10.1038/ng0394-305
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发表时间：
1994-03-01
期刊：
影响因子：
30.8
通讯作者：
NIIKAWA, N
中科院分区：
文献类型：
--
作者：
JINNO, Y;YUN, KK;NIIKAWA, N
我们已经检查了在人体组织中的Wilms肿瘤抑制基因（WT 1）的印记。我们证实，WT1是双等位基因表达的肾脏，然而，在五个9早产胎盘WT1主要或完全从母体等位基因表达。WT1的单等位基因表达也被发现在两个胎儿的大脑。这些数据表明，WT 1可以进行组织特异性印迹。此外，因为WT1的单等位基因表达没有被发现在所有的胎盘检查，WT1印迹可能是遗传多态性的人群内。
We have examined the imprinting of the Wilms' tumour suppressor gene (WT1) in human tissues. We confirm that WT1 is biallelically expressed in the kidney, however, in five of nine preterm placentae WT1 was expressed largely or exclusively from the maternal allele. Monoallelic expression of WT1 was also found in two fetal brains. These data demonstrate that WT1 can undergo tissue specific imprinting. Furthermore, because monoallelic expression of WT1 was not found in all placentae examined, WT1 imprinting may be genetically polymorphic within the human population.