Simulation of Deformation and Aggregation of Two Red Blood Cells in a Stenosed Microvessel by Dissipative Particle Dynamics
Simulation of Deformation and Aggregation of Two Red Blood Cells in a Stenosed Microvessel by Dissipative Particle Dynamics
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通过耗散粒子动力学模拟狭窄微血管中两个红细胞的变形和聚集
DOI：
10.1007/s12013-016-0765-2
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发表时间：
2016-10
影响因子：
2.6
通讯作者：
Fu, Bingmei
中科院分区：
文献类型：
--
作者：
Xiao, Lanlan;Liu, Yang;Chen, Shuo;Fu, Bingmei
用耗散粒子动力学方法模拟了两个红细胞在狭窄微血管中的运动。研究了细胞间相互作用、红细胞变形能力和细胞初始取向对红细胞变形和聚集以及流动阻力的影响。红细胞膜被视为一个三维粗粒度网络模型，细胞间的相互作用是基于消耗介导的假设的莫尔斯势建模。结果表明，当红细胞进入狭窄时，流动阻力急剧增加，并且随着红细胞远离狭窄而迅速减小。特别地，对于初始倾斜角度为90°的一对较硬的红细胞，流动阻力的最大值较大;而较高的流动阻力也可以来自于较强的聚集。对于平行于主流移动的一对较硬的红细胞，当它们的位置更靠近狭窄上游处的血管壁时，由于迁移到狭窄处的血管中心，流动阻力增加。此外，对于具有0°的初始倾斜角的一对红细胞，来自由具有较大变形的一对红细胞形成的聚集体的流动阻力较高。
The motion of two red blood cells in a stenosed microvessel was simulated using dissipative particle dynamics. The effects of intercellular interaction, red blood cell deformability and the initial cell orientation on the deformation and aggregation of the RBCs and on the flow resistance were investigated. The red blood cell membrane was treated as a three-dimensional coarse-grained network model and the intercellular interaction was modeled by the Morse potential based on a depletion-mediated assumption. It is shown that the flow resistance increases dramatically when the red blood cells enter into the stenosis and decreases rapidly as RBCs move away from the stenosis. Particularly, for a pair of stiffer red blood cells with the initial inclination angle of 90°, the maximum value of the flow resistance is larger; while a higher flow resistance can also come from a stronger aggregation. For a pair of stiffer red blood cells moving parallel to the main flow, when their positions are closer to the vessel wall at the upstream of the stenosis, the flow resistance increases due to the migration to the vessel center at the stenosis. In addition, for a pair of red blood cells with the initial inclination angle of 0°, the flow resistance from the aggregate formed by a pair of red blood cells with a larger deformation is higher.