Effect of obesity on platelet reactivity and response to low-dose aspirin.
Effect of obesity on platelet reactivity and response to low-dose aspirin.
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DOI：
10.1111/j.1751-7141.2009.00058.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Becker, Diane M
中科院分区：
文献类型：
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作者：
Bordeaux, Bryan C;Qayyum, Rehan;Becker, Diane M
阿司匹林对血小板功能抑制不足是高危患者心血管事件的预测因子。作者评估了2014人服用阿司匹林81 mg/d前后2周肥胖对血小板反应性的影响。肥胖者的基线血小板反应性更高。比较阿司匹林治疗后的肥胖和非肥胖个体，胶原聚集测定结果为6.7 vs 6.1欧姆，P= 0.008;腺苷二磷酸聚集测定结果为13.1 vs 11.8欧姆，P
Insufficient platelet function suppression by aspirin is a predictor of cardiovascular events in high-risk patients. The authors assessed the impact of obesity on platelet responsiveness before and after 2 weeks of aspirin 81 mg/d in 2014 people. Obese individuals had greater baseline platelet reactivity. Comparing obese and nonobese individuals after aspirin therapy, results for aggregometry to collagen were 6.7 vs 6.1 ohms, P=.008; aggregometry to adenosine diphosphate were 13.1 vs 11.8 ohms,P