Oxidative stress and oxidative damage in chemical carcinogenesis
Oxidative stress and oxidative damage in chemical carcinogenesis
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DOI：
10.1016/j.taap.2009.11.028
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发表时间：
2011-07-15
影响因子：
3.8
通讯作者：
Zhou, Shaoyu
中科院分区：
文献类型：
--
作者：
Klaunig, James E.;Wang, Zemin;Zhou, Shaoyu
活性氧（ROS）可通过多种内源性和外源性来源诱导产生。当细胞内的抗氧化和DNA修复机制被活性氧压倒时，可能导致细胞氧化应激和氧化损伤。由此产生的氧化应激可以破坏关键的细胞大分子和/或调节基因表达途径。化学和物理因素诱发癌症是一个多步骤的过程。这一过程包括多种分子和细胞事件，将正常细胞转化为恶性肿瘤细胞。由ROS生成引起的氧化损伤可以参与癌症过程的所有阶段。ROS的产生与人类癌症的诱导有关联。看来，氧化应激既可能导致也可能改变癌症过程。近年来，DNA氧化修复基因和抗氧化基因多态性（单核苷酸多态性）与人类癌症易感性之间的关系得到了证实。(C) 2011爱思唯尔公司版权所有。
Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways. Cancer induction by chemical and physical agents involves a multi-step process. This process includes multiple molecular and cellular events to transform a normal cell to a malignant neoplastic cell. Oxidative damage resulting from ROS generation can participate in all stages of the cancer process. An association of ROS generation and human cancer induction has been shown. It appears that oxidative stress may both cause as well as modify the cancer process. Recently association between polymorphisms in oxidative DNA repair genes and antioxidant genes (single nucleotide polymorphisms) and human cancer susceptibility has been shown. (C) 2011 Elsevier Inc. All rights reserved.