Measurement of canine pancreatic perfusion using dynamic computed tomography: Influence of input-output vessels on deconvolution and maximum slope methods
Measurement of canine pancreatic perfusion using dynamic computed tomography: Influence of input-output vessels on deconvolution and maximum slope methods
复制标题
DOI：
10.1016/j.ejrad.2009.06.016
复制
发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Yamada, Kazutaka
中科院分区：
文献类型：
--
作者：
Kishimoto, Miori;Tsuji, Yoshihisa;Yamada, Kazutaka
目的：探讨胰腺灌注CT中最大斜率法和反卷积法是否满足前提条件，以及两种算法测量的参数是否相关。方法：对9只比格犬进行检查，注射剂量为5.0 ml s(-1)碘海醇(200 mgI kg(-1))。选择腹主动脉、脾动脉和腹腔动脉作为输入动脉，脾静脉作为输出静脉。对于最大斜率法，我们通过测量曲线下面积（AUC）来确定每条动脉的动脉造影剂体积，并将胰腺中的峰值增强时间与脾静脉中的造影剂出现时间进行比较。对于反卷积方法，计算造影剂的动静脉采集率。我们使用两种算法计算了胰腺组织血流量（TBF）、组织血容量（TBV）和平均通过时间（MTT），并根据血管选择研究了它们的相关性。结果：动脉AUC随着接近胰腺而显着下降（P < 0.01）。在所有情况下，胰腺的峰值时间 (11.5 +/- 1.6) 都比脾静脉中的出现时间 (14.1 +/- 1.6) 短。脾动静脉组合的采集率最高（91.1%），并且是两种算法中TBF、TBV和MTT之间唯一显着相关的组合。结论：选择距离胰腺最近的血管被认为是更合适的先决条件。因此，容器的选择对于比较不同算法获得的半定量参数非常重要。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
Objective: We investigated whether the prerequisite of the maximum slope and deconvolution methods are satisfied in pancreatic perfusion CT and whether the measured parameters between these algorithms are correlated.Methods: We examined nine beagles injected with iohexol (200 mgI kg(-1)) at 5.0 ml s(-1). The abdominal aorta and splenic and celiac arteries were selected as the input arteries and the splenic vein, the output veins. For the maximum slope method, we determined the arterial contrast volume of each artery by measuring the area under the curve (AUC) and compared the peak enhancement time in the pancreas with the contrast appearance time in the splenic vein. For the deconvolution method, the artery-to-vein collection rate of contrast medium was calculated. We calculated the pancreatic tissue blood flow (TBF), tissue blood volume (TBV), and mean transit time (MTT) using both algorithms and investigated their correlation based on vessel selection.Results: The artery AUC significantly decreased as it neared the pancreas (P < 0.01). In all cases, the peak time of the pancreas (11.5 +/- 1.6) was shorter than the appearance time (14.1 +/- 1.6) in the splenic vein. The splenic artery-vein combination exhibited the highest collection rate (91.1%) and was the only combination that was significantly correlated between TBF, TBV, and MTT in both algorithms.Conclusion: Selection of a vessel nearest to the pancreas is considered as a more appropriate prerequisite. Therefore, vessel selection is important in comparison of the semi-quantitative parameters obtained by different algorithms. (C) 2009 Elsevier Ireland Ltd. All rights reserved.