Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
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DOI：
10.1016/s0304-3959(01)00300-1
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发表时间：
2001-08-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, L
中科院分区：
文献类型：
--
作者：
Bajaj, P;Bajaj, P;Arendt-Nielsen, L
高渗盐水能有效刺激肌肉痛觉感受器。通过向人类胫骨前肌肌内灌注0.5 mi高渗生理盐水（6%）来评估骨关节炎（OA）患者的肌肉痛觉过敏。将下肢OA患者（n = 14）与相同数量的年龄和性别匹配的健康对照进行比较。14例OA患者中有10例以膝关节疼痛为最常见的主诉。分别于输注前、即刻、输注后2、5、10、20 min及每10 min记录一次视觉模拟评分（Visual analogue scale， VAS）疼痛强度及疼痛区域评估，直至疼痛消失。OA患者的平均疼痛缓解时间（11.3 +/- 7.9 min）大于对照组（6.04 +/- 2.1 min） （P = 0.025）。OA患者：与对照组相比，右腿输注后VAS疼痛强度增加(P
Hypertonic saline effectively excites muscle nociceptors. Muscle hyperalgesia was assessed in osteoarthritis (OA) by intramuscular infusion of 0.5 mi hypertonic saline (6%) into the tibialis anterior muscle in humans. Patients (n = 14) with OA in the lower extremities were compared with an equal number of age- and sex-matched healthy controls. Ten of the 14 OA patients had pain in the knee joint as the most common presenting complaint. Visual analogue scale (VAS) pain intensity and assessment of pain areas were recorded before infusion and immediately, 2, 5, 10 and 20 min after infusion, and then every 10 min, until the pain vanished. The mean pain offset time in OA patients (11.3 +/- 7.9 min) was larger as compared with the control subjects (6.04 +/- 2.1 min) (P = 0.025). OA patients: had increased pain intensity VAS after the infusion in the right leg compared with controls (P