Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery
Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery
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DOI：
10.1021/nn700040t
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发表时间：
2007-08-01
期刊：
影响因子：
17.1
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Liu, Zhuang;Sun, Xiaoming;Dai, Hongjie
我们发现，通过普通表面活性剂或酸氧化途径非共价或共价预官能化的单壁碳纳米管(SWNTs)存在较大的超分子化学表面积。通过这些途径将聚乙二醇(PEG)官能化的水溶性单壁碳纳米管允许芳香族分子具有惊人的高度pi堆积，包括具有超高负载能力的抗癌药物(阿霉素)、广泛使用的荧光分子(荧光素)以及分子组合。分子与纳米管的结合和释放可以通过改变pH来控制。芳香族分子的pi堆积强度依赖于纳米管的直径，这导致了一种利用合适直径的纳米管材料来控制分子从单壁碳纳米管中释放的方法。这项工作引入了单壁碳纳米管“功能化划分”的概念，即在同一纳米管的表面赋予多种化学物种，如聚乙二醇单壁碳纳米管、药物和荧光标记，它们具有不同的功能。这种化学分配应该会在新型纳米材料的化学、生物和医学应用方面开辟新的机会。
We show that large surface areas exist for supramolecular chemistry on single-walled carbon nanotubes (SWNTs) prefunctionalized noncovalently or covalently by common surfactant or acid-oxidation routes. Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high degrees of pi-stacking of aromatic molecules, including a cancer drug (doxorubicin) with ultrahigh loading capacity, a widely used fluorescence molecule (fluorescein), and combinations of molecules. Binding of molecules to nanotubes and their release can be controlled by varying the pH. The strength of pi-stacking of aromatic molecules is dependent on nanotube diameter, leading to a method for controlling the release rate of molecules from SWNTs by using nanotube materials with suitable diameter. This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube. Such chemical partitioning should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials.