Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H-influenzae type b among Gambian children
Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H-influenzae type b among Gambian children
复制标题
DOI：
10.1086/517440
复制
发表时间：
1998-06-01
影响因子：
6.4
通讯作者：
Greenwood, BM
中科院分区：
文献类型：
--
作者：
Adegbola, RA;Mulholland, EK;Greenwood, BM
在冈比亚婴儿的有效性试验期间，研究了B型流感嗜血杆菌（HiB）多聚核糖基核糖醇磷酸盐-破伤风圆环结合疫苗（HiB/PRP-T）对HiB口咽携带的影响。儿童在2、3和4个月时接种Hib/PRP-T和白喉-破伤风类毒素百日咳（DTP）或单独接种DTP。每年对1000名1-2岁儿童进行为期4年的研究。通过在抗血清琼脂平板上产生晕圈来检测Hib。在接种Hib/PRP-T疫苗并给予DTP的儿童中，携带率（4.4%; 95%置信区间[CI]，3.8%-5.7%）显著低于仅接种DTP疫苗的儿童（11.0%; 95% CI，8.9%-13.0%）（按年调整的保护效果= 60%; 95% CI，44%-72%; P <0.001）。在未接种疫苗的儿童中，Hib携带情况逐年变化。如欧洲和美国的记录所示，Hib结合疫苗可能在不发达社区产生群体保护作用。
The effect of a Haemophilus influenzae type b (Hib) polyribosylribitol phosphate-tetanus toroid conjugate vaccine (Hib/PRP-T) on oropharyngeal carriage of Hib was studied during an efficacy trial in Gambian infants. Children were vaccinated with Hib/PRP-T and diphtheria-tetanus toxoids pertussis (DTP) or DTP alone at ages 2, 3, and 4 months. Groups of 1000 children aged 1-2 years were studied each year for 4 years. Hib was detected by production of a halo on antiserum agar plates. Carriage was significantly lower among children fully vaccinated with Hib/PRP-T given with DTP (4.4%; 95% confidence interval [CI], 3.8%-5.7%) than among children fully vaccinated with DTP alone (11.0%; 95% CI, 8.9%-13.0%) (protective effect adjusted by year = 60%; 95% CI, 44%-72%; P < .001). Hib carriage varied by year among nonvaccinated children. Hib conjugate vaccines are likely to produce a herd protective effect in underdeveloped communities, as recorded in Europe and the United States.