THE TRAMTRACK GENE ENCODES A DROSOPHILA FINGER PROTEIN THAT INTERACTS WITH THE FTZ TRANSCRIPTIONAL REGULATORY REGION AND SHOWS A NOVEL EMBRYONIC EXPRESSION PATTERN
THE TRAMTRACK GENE ENCODES A DROSOPHILA FINGER PROTEIN THAT INTERACTS WITH THE FTZ TRANSCRIPTIONAL REGULATORY REGION AND SHOWS A NOVEL EMBRYONIC EXPRESSION PATTERN
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DOI：
10.1002/j.1460-2075.1990.tb08097.x
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发表时间：
1990-01-01
期刊：
影响因子：
11.4
通讯作者：
TRAVERS, AA
中科院分区：
文献类型：
--
作者：
HARRISON, SD;TRAVERS, AA
我们鉴定了一种果蝇锌指蛋白，它与配对规则基因 fushi-tarazu (ftz) 转录控制区的多个位点结合。编码该蛋白的 mRNA 的表达模式在胚盘形成之前和种带延伸期间基本上与 ftz 的表达模式互补。我们认为该蛋白质可能通过抑制胚胎发生过程中不适当的分割基因转录来发挥作用。编码这种 ftz 启动子结合蛋白的基因被命名为 Tramtrack (ttk)。
We have identified a Drosophila zinc-finger protein, which binds to a number of sites in the transcriptional control regions of the pair-rule gene fushi-tarazu (ftz). The expression pattern of the mRNA that encodes this protein is essentially complementary to that of ftz both prior to blastoderm formation and during germband extension. We propose that the protein may function by repressing inappropriate segmentation gene transcription during embryogenesis. The gene encoding this ftz promoter-binding protein has been named tramtrack (ttk).