Investigation of Atrial Vulnerability by Analysis of the Sinus Node EG From Atrial Fibrillation Models Using a Phase Synchronization Method
Investigation of Atrial Vulnerability by Analysis of the Sinus Node EG From Atrial Fibrillation Models Using a Phase Synchronization Method
复制标题
使用相位同步方法分析心房颤动模型中的窦房结 EG 来研究心房脆弱性
DOI：
10.1109/tbme.2012.2208751
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发表时间：
2012-08
影响因子：
4.6
通讯作者：
Derek Abbott
中科院分区：
文献类型：
--
作者：
Ying Chen;Zhong Wu;Cuiwei Yang;Jun Shao;Kelvin Kian Loong Wong;Derek Abbott
心房颤动（AF）可导致危及生命的心律失常，临床上检测脆弱性的方便手段仍然难以捉摸。我们通过分析房颤动物模型的窦性电图（EG），采用相位同步方法研究心房易损性。使用乙酰胆碱（ACh）诱导的急性房颤犬模型（n = 4），共128个电导线连接到前，后心房的表面，和肺静脉，以形成心电图标测系统。乙酰胆碱注射在不同的浓度与梯形调整。记录了与特定ACh浓度相关的窦性心电图和诱导性房颤心电图。我们假设心房易损性可能与从窦EG提取的相位差矩阵的香农熵（SE）相关。我们的研究表明，SE与同步方法相结合，使窦房结EG进行分析，并用于估计心房脆弱性。
Atrial fibrillation (AF) can result in life-threatening arrhythmia, and a clinically convenient means for detecting vulnerability remains elusive. We investigated atrial vulnerability by analyzing the sinus electrogram (EG) from AF animal models using a phase synchronization method. Using acetylcholine (ACh)-induced acute canine AF models (n = 4), a total of 128 electrical leads were attached to the surface of the anterior and posterior atria, and the pulmonary veins to form an electrocardiological mapping system. ACh was injected at varying concentrations with ladder-type adjustments. Sinus EGs and induced AF EGs that pertain to specific ACh concentrations were recorded. We hypothesize that the atrial vulnerability may be correlated with the Shannon entropy (SE) of the phase difference matrix that is extracted from the sinus EG. Our research suggests that the combination of SE with the synchronization method enables the sinus node EG to be analyzed and used to estimate atrial vulnerability.
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DOI：
10.1113/jphysiol.1955.sp005306
发表时间：
1955-05
期刊：
The Journal of Physiology
影响因子：
--
作者：
J. Burn;E. Williams;J. Walker
通讯作者：
J. Burn;E. Williams;J. Walker
影响因子：
8.6
作者：
Rosenblum, MG;Pikovsky, AS;Kurths, J
通讯作者：
Kurths, J
影响因子：
--
作者：
SHANNON, CE
通讯作者：
SHANNON, CE
影响因子：
20.1
作者：
Kneller, J;Zou, RQ;Nattel, S
通讯作者：
Nattel, S
影响因子：
20.1
作者：
Cardin, Sophie;Libby, Eric;Nattel, Stanley
通讯作者：
Nattel, Stanley