Genetic basis of atherosclerosis: insights from mice and humans.
Genetic basis of atherosclerosis: insights from mice and humans.
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DOI：
10.1161/circresaha.110.230854
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发表时间：
2012-01-20
影响因子：
20.1
通讯作者：
Rader DJ
中科院分区：
文献类型：
--
作者：
Stylianou IM;Bauer RC;Reilly MP;Rader DJ
动脉粥样硬化是一种复杂的遗传性疾病，涉及多种细胞类型和许多不同分子途径的相互作用。动脉粥样硬化的遗传和分子机制已部分通过小鼠模型阐明;至少有100种不同的基因已被证明影响小鼠的动脉粥样硬化。重要的是，无偏倚的全基因组关联研究最近发现了一些与动脉粥样硬化性冠状动脉疾病（CAD）密切相关的新基因座。在这里，我们回顾了从小鼠动脉粥样硬化模型中阐明的遗传数据，以及与人类CAD的显著关联。此外，我们更详细地讨论了这些新的人类CAD位点。小鼠和人类遗传学的结合有可能识别和验证影响动脉粥样硬化的新基因，其中一些可能是新治疗方法的候选者。
Atherosclerosis is a complex and heritable disease involving multiple cell types and the interactions of many different molecular pathways. The genetic and molecular mechanisms of atherosclerosis have in part been elucidated by mouse models; at least 100 different genes have been shown to influence atherosclerosis in mice. Importantly, unbiased genome-wide association studies have recently identified a number of novel loci robustly associated with atherosclerotic coronary artery disease (CAD). Here we review the genetic data elucidated from mouse models of atherosclerosis, as well as significant associations for human CAD. Furthermore, we discuss in greater detail some of these novel human CAD loci. The combination of mouse and human genetics has the potential to identify and validate novel genes that influence atherosclerosis, some of which may be candidates for new therapeutic approaches.