Recent advances of anti-cancer therapies including the use of cell-penetrating peptides
Recent advances of anti-cancer therapies including the use of cell-penetrating peptides
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DOI：
10.1016/j.coph.2019.01.003
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发表时间：
2019-08-01
影响因子：
4
通讯作者：
Neundorf, Ines
中科院分区：
文献类型：
--
作者：
Klimpel, Annika;Luetzenburg, Tamara;Neundorf, Ines
癌症是日益严重的主要公共卫生问题之一，因此开发新的抗癌治疗策略仍然是必要的。常规使用的化疗往往与严重的副作用有关。一个原因是所用药物的细胞渗透性有限，导致整体生物利用度差。在过去的三十年中，细胞穿透肽（CPP）已被广泛研究作为几类货物的有效载体，包括CPP在内的新型治疗应用的开发在当前的癌症研究中发挥了重要作用。这篇综述总结了CPP介导的货物输送的最新趋势，对抗癌治疗的未来影响。
Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. During the last thirty years, cell-penetrating peptides (CPPs) have extensively been studied as efficient vehicles for several classes of cargos, and the development of novel therapeutic applications including CPPs has gained a major role in current cancer research. This review summarizes recent trends in CPP-mediated cargo delivery with a future impact on anti-cancer therapy.