Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases
Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases
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DOI：
10.1038/modpathol.3880175
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发表时间：
2000-09-01
期刊：
影响因子：
7.5
通讯作者：
Weiss, LM
中科院分区：
文献类型：
--
作者：
Chu, PG;Wu, E;Weiss, LM
细胞角蛋白7（CK 7）和细胞角蛋白20（CK 20）是低分子量的细胞角蛋白。它们的解剖学分布通常限于上皮及其肿瘤。我们用CK 7和CK 20单克隆抗体对435例不同器官系统的上皮性肿瘤进行了免疫组化检查。CK 7的表达被认为是在大多数情况下的癌症，除了那些癌来自结肠，前列腺，肾脏和胸腺;类癌的肺和胃肠道起源;和默克尔细胞肿瘤的皮肤。除宫颈鳞癌CK 7阳性率为87%外，其余各类型鳞癌CK 7均为阴性。大约三分之二的恶性间皮瘤病例为CK 7阳性。CK 20阳性见于几乎所有的结直肠癌和默克尔细胞瘤。CK 20在胰腺癌（62%）、胃癌（50%）、胆管癌（43%）和移行细胞癌（29%）中也呈阳性表达。CK 20在其他器官系统的癌中几乎不表达，在恶性间皮瘤中CK 7和CK 20阴性的上皮性肿瘤包括肾上腺皮质癌、生殖细胞瘤、前列腺癌、肾细胞癌和肝细胞癌。
Cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) are low molecular weight cytokeratins. Their anatomic distribution is generally restricted to epithelia and their neoplasms. We surveyed 435 epithelial neoplasms from various organ systems by immunohistochemistry using CK 7 and CK 20 monoclonal antibodies. Expression of CK 7 was seen in the majority of cases of carcinoma, with the exception of those carcinomas arising from the colon, prostate, kidney, and thymus; carcinoid tumors of the lung and gastrointestinal tract origin; and Merkel cell tumor of the skin. The majority of cases of squamous cell carcinoma of various origins were negative for CK 7, except cervical squamous cell carcinoma, in which 87% of cases were positive. Approximately two thirds of cases of malignant mesothelioma were CK7-positive. CK 20 positivity was seen in virtually all cases of colorectal carcinomas and Merkel cell tumors. CK 20-positive staining was also observed in cases of pancreatic carcinomas (62%), gastric carcinoma (50%), cholangiocarcinomas (43%), and transitional cell carcinomas (29%). The expression of CK 20 was virtually absent in carcinomas from other organ systems and In malignant mesothelioma CK 7- and CK 20-negative epithelial neoplasms included adrenal cortical carcinoma, germ cell tumor, prostate carcinoma, renal cell carcinoma, and hepatocellular carcinoma.