Composition of gut microbiota and its association with body mass index and lifestyle factors in a cohort of 7-18 years old children from the American Gut Project
Composition of gut microbiota and its association with body mass index and lifestyle factors in a cohort of 7-18 years old children from the American Gut Project
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DOI：
10.1111/ijpo.12480
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发表时间：
2019-04-01
影响因子：
3.8
通讯作者：
Bruner, D. W.
中科院分区：
文献类型：
--
作者：
Bai, J.;Hu, Y.;Bruner, D. W.
背景肠道菌群与儿童和青少年肥胖之间的关系尚未得到充分研究。目的本研究探讨了肠道菌群与体重指数（BMI）水平之间的关系（体重不足，正常，超重，肥胖）和生活方式（饮食类型和运动频率），方法采用队列研究方法，对美国肠道项目的267名7- 18岁儿童进行研究。用QIIME 2（TM）分析16 S rRNA序列。结果在控制年龄、性别、抗生素和益生菌使用的情况下，影响肠道菌群的显著因素为BMI水平（p = 0.009）、运动频率（p = 0.003）和饮食类型（p = 0.01）。与运动频率（67 OTU）相比，更多的细菌操作分类单位（OTU）与BMI水平（120 OTU）和饮食类型（122 OTU）相关。Actinobacteria门有显着耗尽OTUs的BMI水平，饮食类型和运动频率; Proteobacteria门有显着丰富OTUs的更高的BMI水平和厚壁菌门有显着丰富OTUs的更频繁的exercises.Conclusions显着的协会被发现之间的肠道菌群组成和BMI水平和生活方式控制人口统计学和临床因素在7-18岁的儿童。
Background The association between the gut microbiota and obesity in young children and adolescents is not fully studied.Objectives This study investigated the associations between the gut microbiota and body mass index (BMI) level (underweight, normal, overweight, obese) and lifestyles (diet type and exercise frequency), controlling for demographic and clinical factors among children aged 7-18 years.Methods A cohort study was conducted on 267 children aged 7-18 years from the American Gut Project. 16S rRNA sequences were analysed by QIIME 2 (TM). Composition of gut microbiota and its associations with BMI level, weight change and lifestyles were analysed using linear decomposition model.Results Significant factors affecting the gut microbiota were BMI level (p = 0.009), exercise frequency (p = 0.003) and diet type (p = 0.01), controlling for age, sex and use of antibiotics and probiotics. More bacterial operational taxonomic units (OTUs) were associated with BMI level (120 OTUs) and diet type (122 OTUs) than exercise frequency (67 OTUs). Actinobacteria phylum had significantly depleted OTUs for BMI level, diet type and exercise frequency; Proteobacteria phylum had significantly enriched OTUs for higher BMI level and Firmicutes phylum had significantly enriched OTUs for more frequent exercise.Conclusions Significant associations were found between the gut microbiota composition and BMI level and lifestyles controlling for demographic and clinical factors in children aged 7-18 years.