The emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function.
The emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function.
复制标题
血红素加氧酶及其代谢物在心血管功能调节中的新作用。
DOI：
10.1155/2012/593530
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发表时间：
2012
影响因子：
1.9
通讯作者：
Abraham NG
中科院分区：
文献类型：
--
作者：
Stec DE;Ishikawa K;Sacerdoti D;Abraham NG
血红素氧合酶（HO）是维持心血管系统正常稳态的重要酶。它是负责血红素分解为铁、胆绿素和一氧化碳（CO）气体的酶。胆绿素随后被普遍存在的酶胆绿素还原酶还原为胆红素。HO酶对于红细胞以及细胞内含血红素的蛋白质的周转是必需的。然而，近年来许多研究表明HO及其代谢产物、CO和胆红素在调节整个心血管系统的各种生理过程中起重要作用。更重要的是，已经在许多病理条件下鉴定了HO的改变，并且已经发现诱导HO的疗法在许多心血管疾病过程中提供有益的结果。这期特刊包括9篇原创研究文章、4篇综述文章和1篇临床研究;所有这些文章都强调了HO酶在心血管系统调节中的重要作用。Botros等人，S. Quadri等人，和E. Csongradi等人，用氯化血红素诱导HO-1导致肾血流量和肾小球滤过率（GFR）显著增加，这与尿流量和钠排泄增加有关。用氯化血红素诱导HO-1也减弱了
Heme oxygenase (HO) is an essential enzyme for normal homeostasis of the cardiovascular system. It is the enzyme responsible for the breakdown of heme to iron, biliverdin, and carbon monoxide (CO) gas. Biliverdin is then subsequently reduced to bilirubin by the ubiquitous enzyme biliverdin reductase. HO enzymes are essential for the turnover of red blood cells as well as of heme containing proteins within the cell. However, in recent years numerous studies have demonstrated an important role for HO and its metabolites, CO, and bilirubin in regulating various physiological processes throughout the cardiovascular system. More importantly, alterations in HO have been identified in numerous pathological conditions, and therapies which induce HO have been found to provide beneficial outcomes in numerous cardiovascular disease processes. This special issue consists of 9 original research articles, 4 review articles, and 1 clinical study; all of which highlight the important role that HO enzymes have in the regulation of the cardiovascular system.The important role of HO in the regulation of kidney function and blood pressure is highlighted in studies by F. Botros et al., S. Quadri et al., and E. Csongradi et al. HO-1 induction with hemin results in marked increases in renal blood flow and glomerular filtration rate (GFR) which are associated with increases in urine flow and sodium excretion. HO-1 induction with hemin also attenuates the