Hepatic stem cells: From bone marrow cells to hepatocytes
Hepatic stem cells: From bone marrow cells to hepatocytes
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DOI：
10.1006/bbrc.2001.4270
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发表时间：
2001-02-16
影响因子：
3.1
通讯作者：
Mitaka, T
中科院分区：
文献类型：
--
作者：
Mitaka, T
在肝脏发育和系统性疾病发生时，造血和肝脏环境有着密切的关系。最近，从啮齿类动物和人类的骨髓中分离的移植细胞已经显示出在肝脏中分化成被认为是肝干细胞的卵圆细胞和肝细胞。然后，纯化的造血干细胞被证明有能力取代遗传性酪氨酸血症小鼠的原始肝细胞。本文就肝干细胞间的相互作用进行综述，并提出肝干细胞分化的假说。(C)北京：科学出版社.
Hematopoiesis and the hepatic environment are known to have a close relationship at the time of hepatic development and systemic diseases. Recently, transplanted cells isolated from bone marrow of rodents and humans have been shown to differentiate into oval cells, which are considered to be hepatic stem cells, and hepatocytes in the liver. Then, purified hematopoietic stem cells were shown to have the ability to replace original liver cells in mice with hereditary tyrosinemia. In this review the interactions between hepatic stem cells are summarized and a hypothesis of hepatic differentiation will be proposed. (C) 2001 Academic Press.