Cycle delay in irradiated cytochalasin‐induced polykaryons. Does cytoskeleton status affect cell cycle checkpoints?
Cycle delay in irradiated cytochalasin‐induced polykaryons. Does cytoskeleton status affect cell cycle checkpoints?
复制标题
受辐射的细胞松弛素诱导的多核细胞的周期延迟是否会影响细胞周期检查点？
作者：
H. Davies;J. Court
在137Cs照射CHO-K1细胞后，观察到允许正常分裂的细胞出现G2延迟，而通过细胞松弛素B诱导成巨细胞的细胞在2C-8C转换中表现出最小的延迟，这表明胞质分裂的抑制导致了一个或多个细胞周期检查点的改变。我们推测，这可能是损伤耐受性的结果，也可能是由于细胞骨架的重组而导致的反馈环路，从而阻止了细胞质分裂。
Following exposure of CHO‐K1 cells to137Cs irradiation at doses up to 20Gy, a delay in G2 was observed to occur in cells permitted to divide normally, while cells induced to become giants by means of cytochalasin B demonstrated a minimal delay in the transition 2C–8C suggesting that the inhibition of cytokinesis results in modification of one or more cell cycle checkpoints. We postulate that this may occur as a consequence of damage tolerance, or by a feedback loop resulting from the reorganisation of the cytoskeleton that precludes cytokinesis.
影响因子：
11.2
作者：
R. Muschel;Hong Bing Zhang;G. Iliakis;W. Gillies McKenna;Radiation Oncology
通讯作者：
R. Muschel;Hong Bing Zhang;G. Iliakis;W. Gillies McKenna;Radiation Oncology
蛋白激酶抑制剂 2-氨基嘌呤和 6-二甲基氨基嘌呤在哺乳动物细胞中诱导过早有丝分裂。
DOI：
--
发表时间：
1990
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子：
--
作者：
Schlegel,R;Belinsky,GS;Harris,MO
通讯作者：
Harris,MO
辐射对新克隆和表征的大鼠细胞周期蛋白 B mRNA 表达的影响。
DOI：
10.1016/0360-3016(94)90151-1
发表时间：
1994
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
Markiewicz,DA;McKenna,WG;Flick,MB;Maity,A;Muschel,RJ
通讯作者：
Muschel,RJ