Magnetic resonance imaging demonstrates gyral abnormalities in Tourette syndrome.
Magnetic resonance imaging demonstrates gyral abnormalities in Tourette syndrome.
复制标题
磁共振成像显示抽动秽语综合症的脑回异常。
DOI：
10.1002/jdn.10209
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Levman,Jacob
中科院分区：
文献类型：
--
作者：
McCann,Bernadette;Lam,MelanieY;Shiohama,Tadashi;Ijner,Prahar;Takahashi,Emi;Levman,Jacob
多发性抽动症(TS)是一种以不自主和重复运动为特征的神经系统疾病，称为抽搐。对39例患有TS的儿童和青少年的磁共振成像(MRI)扫描进行了回顾性分析，并随后与834名神经典型对照的MRI扫描进行了比较。本研究的目的是找出TS患者运动回路区域的差异，以加深我们对它们在运动控制中的干扰(即运动抽搐)的理解。通过每次MRI扫描测量特定运动区的体积、皮质厚度、表面积和表面曲率。结果显示，与神经典型对照组相比，TS组额叶下回的盖部和三角部的表面曲率增大。这些新的发现为TS患者运动回路区域的表面曲率差异提供了一些初步证据，这可能与已知的运动和发声痉挛有关。
Tourette syndrome (TS) is a neurological disorder characterized by involuntary and repetitive movements known as tics. A retrospective analysis of magnetic resonance imaging (MRI) scans from 39 children and adolescents with TS was performed and subsequently compared with MRI scans from 834 neurotypical controls. The purpose of this study was to identify any differences in the regions of motor circuitry in TS to further our understanding of their disturbances in motor control (i.e., motor tics). Measures of volume, cortical thickness, surface area, and surface curvature for specific motor regions were derived from each MRI scan. The results revealed increased surface curvature in the opercular part of the inferior frontal gyrus and the triangular part of the inferior frontal gyrus in the TS group compared with the neurotypical control group. These novel findings offer some of the first evidence for surface curvature differences in motor circuitry regions in TS, which may be associated with known motor and vocal tics.