Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: A population-based study
Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: A population-based study
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DOI：
10.1093/oxfordjournals.aje.a009735
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发表时间：
1999-05-15
影响因子：
5
通讯作者：
Wajda, A
中科院分区：
文献类型：
--
作者：
Bernstein, CN;Blanchard, JF;Wajda, A
本研究的目的是评估行政卫生数据在人群基础上识别炎症性肠道疾病患者的准确性和实用性，并确定该疾病在加拿大马尼托巴省的发病率和流行率。根据1984年至1995年《国际疾病分类，第九次修订，临床修改》代码，使用马尼托巴卫生部（该省唯一的保险公司）提供的数据，确定患有克罗恩病或溃疡性结肠炎的居民的医生和/或医院接触者。在5182名符合条件的个人中，4514人邮寄了问卷，2725人回复了问卷。病例定义为有五次或以上独立医疗接触并有其中一种诊断的个体，如果他们在当地居住不到2年，则有三次或以上此类接触。与自我报告或图表回顾相比，研究案例定义的准确性较高。1989-1994年年龄和性别调整后的克罗恩病年发病率为14.6/10万，溃疡性结肠炎年发病率为14.3/10万。1994年克罗恩病患病率为198.5/10万，溃疡性结肠炎患病率为169.7/10万。总之，作者已经成功建立并验证了基于行政数据的炎症性肠病人群数据库。曼尼托巴省炎症性凉亭病的高发病率和动态流行病学表明存在重要的环境危险因素，值得进一步调查。
The aim of this study was to assess the accuracy and utility of administrative health data in identifying persons with inflammatory bower disease on a population basis and to determine the incidence and prevalence of this disease in the Canadian province of Manitoba. The data from Manitoba Health (the province's single insurer) were used to identify residents with physician and/or hospital contacts for Crohn's disease or ulcerative colitis based on International Classification of Diseases, Ninth Revision, Clinical Modification, codes between 1984 and 1995. Of 5,182 eligible individuals, 4,514 were mailed questionnaires and 2,725 responded. Cases were defined as individuals with five or more separate medical contacts with one of these diagnoses or three or more such contacts if they were resident for less than 2 years. The accuracy of the study case definitions was high when compared with either self-report or chart review. The 1989-1994 age- and sex-adjusted annual incidence was 14.6/100,000 for Crohn's disease and 14.3/100,000 for ulcerative colitis. The prevalence of Crohn's disease in 1994 was 198.5/100,000, and that of ulcerative colitis was 169.7/100,000. In conclusion, the authors have successfully established and validated a population-based database of inflammatory bowel disease based on administrative data. The high incidence rates and dynamic epidemiology of inflammatory bower disease in Manitoba indicate the presence of important environmental risk factors, which warrants further investigation.