Exclusion of inflammation in the differential diagnosis of an elevated prostate-specific antigen (PSA)
Exclusion of inflammation in the differential diagnosis of an elevated prostate-specific antigen (PSA)
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DOI：
10.1016/j.urolonc.2008.04.002
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Catalona, William J.
中科院分区：
文献类型：
--
作者：
Loeb, Stacy;Gashti, Sara N.;Catalona, William J.
前列腺炎症可导致血清 PSA 浓度升高并扰乱 PSA 动力学的使用。这可能会产生相当大的临床后果，因为这些测量构成了重要临床决策的基础。因此，人们一直在研究减少炎症干扰的方法，包括在一段时间的观察或经验性抗生素疗程后重复 PSA 测量。本文回顾了前列腺炎引起的 PSA 升高的证据，并描述了关于减少其对前列腺癌筛查的混杂影响的最佳方法的争议。 (C) 2009 Elsevier Inc. 保留所有权利。
Prostate inflammation can lead to an elevation in the serum PSA concentration and confound the use of PSA kinetics. This can have considerable clinical consequences, since these measurements form the basis for important clinical decisions. Thus, there has been investigation into ways to decrease the confounding from inflammation, including repeat PSA measurements after a period of observation or a course of empiric antibiotics. This article reviews the evidence about elevations in PSA due to prostatitis and describes the controversy over the optimal approach to reduce its confounding impact on prostate cancer screening. (C) 2009 Elsevier Inc. All rights reserved.