The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase
The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase
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鞣花单宁三聚体 rugosin G 抑制重组人组氨酸脱羧酶
DOI：
10.1080/09168451.2019.1606695
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kikuzaki Hiroe
中科院分区：
文献类型：
--
作者：
Nitta Yoko;Ito Hideyuki;Komori Hirohumi;Ueno Hiroshi;Takeshima Daiki;Ito Mikiko;Sakaue Motoyoshi;Kikuzaki Hiroe
从红玫瑰花瓣水溶性组分中分离得到鞣花单宁三聚体Rugosin G，研究其对重组人组氨酸脱羧酶的抑制活性。与鞣花单宁单体和具有大环结构的二聚体（oenothein B）相比，Rugosin G显示出有效的抑制作用，表明Rugosin G的有效抑制作用归因于其线性寡聚体构象。
Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation.Abbreviations:HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate