AN ID-RELATED HELIX LOOP HELIX PROTEIN ENCODED BY A GROWTH FACTOR-INDUCIBLE GENE
AN ID-RELATED HELIX LOOP HELIX PROTEIN ENCODED BY A GROWTH FACTOR-INDUCIBLE GENE
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DOI：
10.1073/pnas.88.5.1815
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发表时间：
1991-03-01
影响因子：
11.1
通讯作者：
NATHANS, D
中科院分区：
文献类型：
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作者：
CHRISTY, BA;SANDERS, LK;NATHANS, D
一种编码螺旋-环-螺旋蛋白的mRNA，我们命名为HLH 462，在小鼠3 T3细胞中作为对生长因子和其他信号传导剂的立即早期转录反应的一部分被诱导。 RNA存在于许多小鼠组织和发育中的小鼠胎儿中。 HLH 462基因已经通过种间回交分析定位到小鼠4号染色体的远端区域。 在螺旋-环-螺旋区，HLH 462与Id蛋白和果蝇emc蛋白密切相关。 像Id一样，HLH 462缺乏DNA结合所需的碱性区域，并且它抑制其他螺旋-环-螺旋蛋白的DNA结合活性。 在其结构和功能相似的基础上，以Id，我们认为，HLH 462可能会抑制螺旋-环-螺旋转录因子在细胞生长反应和发育过程中的活动。
An mRNA encoding a helix-loop-helix protein that we have named HLH462 is induced in mouse 3T3 cells as part of the immediate early transcriptional response to growth factors and other signaling agents. The RNA is present in a number of mouse tissues and in the developing mouse fetus. The HLH462 gene has been mapped by interspecific backcross analysis to the distal region of mouse chromosome 4. In its helix-loop-helix region HLH462 is closely related to the Id protein and the Drosophila emc protein. Like Id, HLH462 lacks a basic region required for DNA binding, and it inhibits the DNA-binding activities of other helix-loop-helix proteins. On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development.