ANTAGONISM BY THEOPHYLLINE OF RESPIRATORY INHIBITION INDUCED BY ADENOSINE
ANTAGONISM BY THEOPHYLLINE OF RESPIRATORY INHIBITION INDUCED BY ADENOSINE
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DOI：
10.1152/jappl.1985.59.5.1428
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
KILEY, JP
中科院分区：
文献类型：
--
作者：
ELDRIDGE, FL;MILLHORN, DE;KILEY, JP
在19只经迷走神经切除的猫中，通过伺服控制呼吸机保持其终期二氧化碳分压不变，研究了腺苷类似物L-2-N6-（苯异丙基）腺苷（PIA）和甲基黄嘌呤（茶碱）对呼吸的影响。综合膈神经活动被用来表示输出。我们的研究结果表明，无论是全身给药还是进入第三脑室，PIA都能抑制呼吸。系统给予茶碱刺激呼吸。茶碱静脉注射或进入第三心室不仅逆转了先前给予PIA的抑郁作用，而且使呼吸进一步增加到高于对照水平。先前全身给予茶碱阻断呼吸和随后给予PIA的降压作用。任何一种药物对髓细胞外液pH的影响都不能解释结果。我们得出结论，腺苷类似物PIA可以抑制大脑中参与呼吸控制的神经元，其作用被茶碱阻断。我们认为腺苷作为呼吸的强张性调节剂，茶碱通过腺苷在神经元受体位置的竞争性拮抗刺激呼吸。
The effects on respiration of an analogue of adenosine, L-2-N6-(phenylisopropyl)adenosine (PIA), and of the methylxanthine, theophylline, were determined in 19 vagotomized glomectomized cats whose end-tidal PCO2 were kept constant by means of a servo-controlled ventilator. Integrated phrenic nerve activity was used to represent output. Our results show that PIA, whether given systemically or into the third cerebral ventricle, depressed respiration. Systemically administered theophylline stimulated respiration. Theophylline given intravenously, or into the third ventricle not only reversed the depressive effects of previously administered PIA but caused further increases of respiration above the control level. Prior systemic administration of theophylline blocked both respiration and hypotensive effects of subsequently administered PIA. Effects of either agent on medullary extracellular fluid pH did not explain the results. We conclude that the adenosine analogue PIA, acts to inhibit neurons in the brain that are involved in the control of respiration and that its effects are blocked by theophylline. We suggest that adenosine acts as a tonic modulator or respiration and that theophylline stimulates breathing by competitive antagonism of adenosine at neuronal receptor sites.