An approach to the structure and function of the glomerular mesangium.
An approach to the structure and function of the glomerular mesangium.
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肾小球系膜结构和功能的一种方法。
DOI：
10.1681/asn.v210s65
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
H. Latta
中科院分区：
文献类型：
--
作者：
H. Latta
肾小球系膜是一种结缔组织树，生长于肾小球的血管极并支持肾小球毛细血管。它部分被基底膜覆盖，基底膜跟随上皮细胞从外周肾小球毛细血管壁覆盖在支持组织上。毛细血管内皮通常没有单独的基底膜。内皮有直接通向系膜的开窗，允许血浆和示踪剂流入系膜。开窗部分地限制（或筛分）平均长度超过405 A的颗粒进入。示踪剂在细胞间通道中移动，并被系膜侧的基底膜或细胞间通道中的系膜基质丝过滤和浓缩。血流、基质和示踪剂浓度的不规则分布可以解释肾小球疾病中不规则的小叶反应。两个主要的流动途径似乎是（1）通过基底膜和上皮足突之间形成肾小球滤液的一部分，（2）通过肾小球系膜窗进入输出毛细血管。固有系膜细胞现在可以被认为是与结缔组织基质的产生相关的肌成纤维细胞。这些细胞保持基底膜以维持肾小球毛细血管的形状，它们容易膨胀，并且它们可以在适当的刺激下像平滑肌细胞一样收缩。这些反应可能使它们能够控制肾小球疾病中通过毛细血管网络的血液流动。肾小球系膜细胞可在24 h内吸收大量异物。固有系膜细胞和单核细胞可在疾病中数量增加。（250字处删节）
The mesangium of the glomerulus is a connective tissue tree arising at the vascular pole of the glomerulus and supporting the glomerular capillaries. It is partly covered by a basement membrane that follows the epithelial cells from the peripheral glomerular capillary wall over the supporting tissue. The capillary endothelium does not normally have a separate basement membrane. The endothelium has fenestrations that open directly into the mesangium and allow blood plasma and tracers to flow into the mesangium. The fenestrations partially restrict (or sieve) particles over 405 A in mean length from entry. Tracers move in intercellular channels and are filtered and concentrated by the basement membrane at the sides of the mesangium or by mesangial matrix filaments in the channels between cells. The irregular distributions of flow, matrix, and concentrations of tracers may account for irregular lobular reactions in glomerular disease. Two main pathways of flow seem to be (1) through the basement membrane and between the epithelial foot processes to form part of the glomerular filtrate and (2) into the efferent capillaries through their mesangial fenestrations. Intrinsic mesangial cells can now be regarded as myofibroblasts associated with the production of the connective tissue matrix. These cells hold the basement membrane to maintain the shape of the glomerular capillaries, they swell readily, and they can constrict like smooth muscle cells with appropriate stimulation. These reactions may enable them to control the flow of blood through the capillary network in glomerular disease. Mesangial cells can take up large amounts of foreign material within 24 h. Intrinsic mesangial cells and monocytes can increase in numbers in disease.(ABSTRACT TRUNCATED AT 250 WORDS)
大鼠系膜吞噬细胞的起源及其白细胞共同抗原的表达。
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Schreiner,GF;Unanue,ER
通讯作者：
Unanue,ER