The fate of monocytes in atherosclerosis.
The fate of monocytes in atherosclerosis.
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DOI:
10.1111/j.1538-7836.2009.03423.x
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发表时间:
2009-07
期刊:
影响因子:
--
通讯作者:
Randolph GJ
中科院分区:
文献类型:
--
作者:
Randolph GJ
Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.
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