Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination.
Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination.
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DOI：
10.1016/j.pharmthera.2020.107647
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发表时间：
2021-01
影响因子：
13.5
通讯作者：
You G
中科院分区：
文献类型：
--
作者：
Zhang J;Wang H;Fan Y;Yu Z;You G
有机阴离子转运蛋白（OAT）家族成员主要在肾、肝、胎盘、肠和脑中表达。这些转运蛋白在临床药物、农药、信号分子、重金属偶联物、植物药成分和毒素的处理中发挥重要作用，因此对维持系统稳态至关重要。燕麦蛋白表达和功能的改变导致了许多药物的治疗效果和毒性的个体内部和个体之间的差异，以及许多病理生理状况。因此，这些转运蛋白的活性必须受到高度调控才能发挥其正常功能。本文将对肾脏oat调控的细胞和分子机制的最新进展进行综述，重点介绍翻译后修饰（PTM）、这些PTM之间的串扰以及oat的遥感和信号网络。这些知识将为了解这些转运蛋白在健康和疾病中的作用提供重要的见解。
The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, and therefore critical for maintaining systemic homeostasis. Alterations in the expression and function of OATs contribute to the intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs, and to many pathophysiological conditions. Consequently, the activity of these transporters must be highly regulated to carry out their normal functions. This review will present an update on the recent advance in understanding the cellular and molecular mechanisms underlying the regulation of renal OATs, emphasizing on the post-translational modification (PTM), the crosstalk among these PTMs, and the remote sensing and signaling network of OATs. Such knowledge will provide significant insights into the roles of these transporters in health and disease.
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影响因子：
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作者：
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DOI：
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发表时间：
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