Cadmium interacts with the transport of essential micronutrients in the mammary gland-A study in rural Bangladeshi women
Cadmium interacts with the transport of essential micronutrients in the mammary gland-A study in rural Bangladeshi women
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DOI：
10.1016/j.tox.2008.12.009
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发表时间：
2009-03-04
期刊：
影响因子：
4.5
通讯作者：
Vahter, Marie
中科院分区：
文献类型：
--
作者：
Kippler, Maria;Loennerdal, Bo;Vahter, Marie
尽管母乳中有毒金属镉的浓度通常较低（<1μg/L），但实验研究表明对哺乳后代的神经行为和内分泌有影响。本研究的目的是通过评估镉与必需微量营养素的相互作用来阐明镉如何转运到母乳中。这项研究是在孟加拉国农村地区马特拉布（Matlab）的孕妇中进行的一项食品和微量营养素补充试验的基础上进行的，该地区营养不良现象普遍，镉暴露水平相对较高。我们测量了母乳中的镉（BM-Cd；中值 0.14 μg/kg；范围 < 0.050-1.0 μg/kg）、红细胞中的镉（Ery-Cd；中值 1.5 μg/kg；范围 0.46-4.8 μg/kg）和尿液中的镉（U-Cd；中值 0.63 μg/L；范围 0.050-4.5 μg/kg）。 g/L)，使用电感耦合等离子体质谱 (ICPMS)。我们发现 Ery-Cd 和 BM-Cd 之间存在显着的正相关关系，母乳-血浆比率类似于 3-4，表明镉从血浆到母乳的转运没有障碍。 BM-Cd 与母乳中的锰（r(s) = 0.56；p < 0.01）和铁（r(s) = 0.55：p < 0.01）呈正相关，但与血浆铁蛋白无关。另一方面，BM-Cd 与 BM-Ca 呈负相关（r(s) = -0.17；p = 0.05），表明镉抑制钙向母乳的转运。总之，本研究可能表明，镉与铁和锰具有共同的转运蛋白，可转运至母乳，但会抑制钙向母乳的分泌。 (c) 2008 Elsevier Ireland Ltd. 保留所有权利。
Although the concentrations of the toxic metal cadmium in breast milk are generally low (< 1 mu g/L), experimental studies indicated neurobehavioral and endocrine effects in the suckling offspring. The aim of the present study was to elucidate how cadmium is transported to breast milk by assessing interactions with essential micronutrients. The study is nested into a food and micronutrient supplementation trial conducted among pregnant women in Matlab, a rural area in Bangladesh, where malnutrition is prevalent and the cadmium exposure is relatively high. We measured cadmium in breast milk (BM-Cd; median 0.14 mu g/kg; range < 0.050-1.0 mu g/kg), in erythrocytes (Ery-Cd; median 1.5 mu g/kg; range 0.46-4.8 mu g/kg) and in urine (U-Cd; median 0.63 mu g/L; range 0.050-4.5 mu g/L), using inductively coupled plasma mass spectrometry (ICPMS). We found a significant positive association between Ery-Cd and BM-Cd and a breast milk-plasma ratio of similar to 3-4, indicating no barrier against cadmium transport from plasma to breast milk. BM-Cd was positively associated with manganese (r(s) = 0.56; p < 0.01) and iron (r(s) = 0.55: p < 0.01) in breast milk, but not with plasma ferritin. On the other hand, BM-Cd was negatively associated with BM-Ca (r(s) = -0.17; p = 0.05), indicating that cadmium inhibits the transport of calcium to breast milk. In conclusion, the present study may indicate that cadmium shares common transporters with iron and manganese for transfer to breast milk, but inhibits secretion of calcium to breast milk. (c) 2008 Elsevier Ireland Ltd. All rights reserved.