Paradigm shift from ‘Compartment’ to ‘Zone’ in the understanding of organelles
Paradigm shift from ‘Compartment’ to ‘Zone’ in the understanding of organelles
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细胞器理解范式从“区室”到“区域”的转变
DOI：
10.1093/jb/mvy107
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Nishitoh Hideki
中科院分区：
文献类型：
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作者：
NA. Nomann;S. Ito;MR. Hasan;Y. Qiu;T. Saito;丸山健太;Nishitoh Hideki
细胞器是由脂质双层界定的细胞内区室，在调节各种细胞事件中发挥特定作用。细胞器功能障碍导致多种疾病的病理机制。超分辨荧光显微镜的发展和流行使得许多细胞生物学家能够表征各种功能区域和细胞器动力学。这些局部功能细胞器区域被命名为“区”，本期的三篇综述文章总结了三个不同的细胞器区，即“反应区”，“通讯区”和“排序区”。这一最新的细胞器概念可能揭示一个新的生物学方面和未解决的疾病的机制的阐明。
Organelles are intracellular compartments that are delineated by lipid bilayers and play specific roles in regulating various cellular events. Organelle dysfunction contributes to the pathological mechanisms of various diseases. The development and prevalence of super-resolved fluorescence microscopy have enabled the characterization of various functional regions and organellar dynamics by a number of cell biologists. These local functional organelle regions are named ‘zones’, and three review articles in this issue summarize three different organelle zones, namely, the ‘Response zone’, ‘Communication zone’ and ‘Sorting zone’. This newest organellar concept may shed light on a novel biological aspect and the elucidation of mechanisms of unresolved diseases.