Chronic traumatic brain injury associated with boxing
Chronic traumatic brain injury associated with boxing
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DOI：
10.1055/s-2000-9826
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发表时间：
2000-01-01
影响因子：
2.7
通讯作者：
Jordan, BD
中科院分区：
文献类型：
--
作者：
Jordan, BD
与拳击相关的慢性创伤性脑损伤（CTBI）发生在大约20%的职业拳击手中。与CTBI相关的风险因素包括暴露增加（即，职业生涯的持续时间，退休年龄，总的比赛次数），表现不佳，增加陪练，载脂蛋白（APOE）基因型。临床上，表现出CTBI的拳击手将表现出不同程度的运动、认知和/或行为障碍。CTBI的严重形式被称为拳击员痴呆。CTBI的诊断取决于记录进展性神经系统疾病，该疾病与可归因于脑创伤且无法通过替代病理生理过程解释的CTBI临床病理学一致。在病理学上，CTBI与阿尔茨海默病具有许多共同特征（即，神经胶质三角、弥漫性淀粉样斑块、乙酰胆碱缺乏和/或tau免疫反应性）。治疗CTBI的主要方法是预防，然而，可以使用用于治疗阿尔茨海默病和/或帕金森综合征的药物。
Chronic traumatic brain injury (CTBI) associated with boxing occurs in approximately 20% of professional boxers. Risk factors associated with CTBI include increased exposure (i.e., duration of career, age of retirement, total number of bouts), poor performance, increased sparring, and apolipoprotein (APOE) genotype. Clinically, boxers exhibiting CTBI will present with varying degrees of motor, cognitive, and/or behavioral impairments. The severe form of CTBI is referred to as dementia pugilistica. The diagnosis of CTBI is dependent upon documenting a progressive neurological condition that is consistent with the clinical symptomatology of CTBI attributable to brain trauma and unexplainable by an alternative pathophysiological process. Pathologically, CTBI shares many characteristics with Alzheimer's disease (i.e,, neurofibrillary triangles, diffuse amyloid plaques, acetylcholine deficiency, and/or tau immunoreactivity), The mainstay of treatment of CTBI is prevention, however medications used in the treatment of Alzheimer's disease and/or parkinsonism may be utilized.