LOCALIZATION OF ULTRASOUND-INDUCED IN VIVO NEUROSTIMULATION IN THE MOUSE MODEL
LOCALIZATION OF ULTRASOUND-INDUCED IN VIVO NEUROSTIMULATION IN THE MOUSE MODEL
复制标题
DOI：
10.1016/j.ultrasmedbio.2014.01.020
复制
发表时间：
2014-07-01
影响因子：
2.9
通讯作者：
Pauly, Kim Butts
中科院分区：
文献类型：
--
作者：
King, Randy L.;Brown, Julian R.;Pauly, Kim Butts
使用超声波刺激和调节神经活动的发展提高了使用超声波作为大脑研究中新的研究和治疗工具的可能性。尽管超声波引起的神经刺激现象已有数十年的悠久历史，但迄今为止，几乎没有证据表明其对大脑有明显的局部效应，而这是该技术真正发挥作用的必要条件。在这里，我们报告了对小鼠运动皮层的头侧和尾侧区域进行超声处理的明显可区分的效果。当对运动皮层的两个不同区域进行声波处理时，通过标准化肌电图测量的颈部和尾部区域的运动反应发生显着变化。响应延迟根据超声处理位置的不同而显着变化，这表明不同的神经回路根据超声波束的精确焦点被激活。总而言之，我们的研究结果提供了良好的证据，证明超声神经刺激能够靶向小鼠运动皮层的选择性部分，这一进展应有助于为在包括人类在内的大型动物模型中开发新应用奠定基础。 （电子邮件：rlking@stanford.edu） (c) 2014 年世界超声医学与生物学联合会。
Developments in the use of ultrasound to stimulate and modulate neural activity have raised the possibility of using ultrasound as a new investigative and therapeutic tool in brain research. Although the phenomenon of ultrasound-induced neurostimulation has a long history dating back many decades, until now there has been little evidence of a clearly localized effect in the brain, a necessary requirement for the technique to become genuinely useful. Here we report clearly distinguishable effects in sonicating rostral and caudal regions of the mouse motor cortex. Motor responses measured by normalized electromyography in the neck and tail regions changed significantly when sonicating the two different areas of motor cortex. Response latencies varied significantly according to sonication location, suggesting that different neural circuits are activated depending on the precise focus of the ultrasound beam. Taken together, our findings present good evidence of the ability to target selective parts of the motor cortex with ultrasound neurostimulation in the mouse, an advance that should help to set the stage for developing new applications in larger animal models, including humans. (E-mail: rlking@stanford.edu) (c) 2014 World Federation for Ultrasound in Medicine & Biology.