Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.
Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.
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DOI：
10.3390/jcm12165176
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发表时间：
2023-08-09
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性疼痛在儿科人群中非常普遍。从急性疼痛到慢性疼痛的转变涉及许多因素。目前，有概念模型的建议，但他们缺乏一个机械健全的综合理论，考虑到儿童发展的阶段。客观的生物标志物对于疼痛慢性化的病理阶段的诊断、危险分层和预后是非常需要的。在这篇文章中，我们总结了目前的证据机制和生物标志物的急性慢性疼痛的转变，在婴儿和儿童通过发展透镜。目的是找出差距，并概述未来的方向，为基础和临床研究，以发展知情的理论，疼痛慢性化的儿科人口。首先，概述了儿童疼痛慢性化的客观生物标志物的重要性，然后总结了成人急性疼痛向慢性疼痛转变机制的现有证据，以与儿科人群疼痛慢性化的发育机制形成对比。证据表明，慢性疼痛可能有其起源于侮辱在生命的早期，这总理的儿童慢性疼痛的发展在以后的生活。此外，可用的遗传，表观遗传，心理物理，电生理，神经影像，神经免疫，和性别机制在婴儿和年龄较大的儿童。最后，未来的发展方向进行了讨论，重点是研究差距，翻译和临床意义。利用发展机制框架，告知临床决策和战略，预防和管理急性疼痛的儿童慢性疼痛的转变，突出。
Chronic pain is highly prevalent in the pediatric population. Many factors are involved in the transition from acute to chronic pain. Currently, there are conceptual models proposed, but they lack a mechanistically sound integrated theory considering the stages of child development. Objective biomarkers are critically needed for the diagnosis, risk stratification, and prognosis of the pathological stages of pain chronification. In this article, we summarize the current evidence on mechanisms and biomarkers of acute to chronic pain transitions in infants and children through the developmental lens. The goal is to identify gaps and outline future directions for basic and clinical research toward a developmentally informed theory of pain chronification in the pediatric population. At the outset, the importance of objective biomarkers for chronification of pain in children is outlined, followed by a summary of the current evidence on the mechanisms of acute to chronic pain transition in adults, in order to contrast with the developmental mechanisms of pain chronification in the pediatric population. Evidence is presented to show that chronic pain may have its origin from insults early in life, which prime the child for the development of chronic pain in later life. Furthermore, available genetic, epigenetic, psychophysical, electrophysiological, neuroimaging, neuroimmune, and sex mechanisms are described in infants and older children. In conclusion, future directions are discussed with a focus on research gaps, translational and clinical implications. Utilization of developmental mechanisms framework to inform clinical decision-making and strategies for prevention and management of acute to chronic pain transitions in children, is highlighted.
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影响因子：
2.6
作者：
通讯作者：
--
影响因子：
4
作者：
Markman, John D.;Schnitzer, Thomas J.;Perrot, Serge;Beydoun, Said R.;Ohtori, Seiji;Viktrup, Lars;Yang, Ruoyong;Bramson, Candace;West, Christine R.;Verburg, Kenneth M.
通讯作者：
Verburg, Kenneth M.
DOI：
10.1016/j.pmn.2020.05.007
发表时间：
2021-03
期刊：
Pain management nursing : official journal of the American Society of Pain Management Nurses
影响因子：
--
作者：
Perry M;Sieberg CB;Young EE;Baumbauer K;Singh V;Wong C;Starkweather A
通讯作者：
Starkweather A
影响因子：
3.7
作者：
Chidambaran V;Pilipenko V;Jegga AG;Geisler K;Martin LJ
通讯作者：
Martin LJ
影响因子：
5.6
作者：
Tauzin, Manon;Gouyon, Beatrice;Hirt, Deborah;Carbajal, Ricardo;Gouyon, Jean-Bernard;Brunet, Anne-Claire;Ortala, Matthieu;Goro, Seydou;Jung, Camille;Durrmeyer, Xavier
通讯作者：
Durrmeyer, Xavier