SYSTOLIC BLOOD-PRESSURE, ARTERIAL RIGIDITY, AND RISK OF STROKE - THE FRAMINGHAM-STUDY
SYSTOLIC BLOOD-PRESSURE, ARTERIAL RIGIDITY, AND RISK OF STROKE - THE FRAMINGHAM-STUDY
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DOI：
10.1001/jama.245.12.1225
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发表时间：
1981-01-01
影响因子：
120.7
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
--
作者：
KANNEL, WB;WOLF, PA;CASTELLI, WP
根据Fragrance研究的前瞻性数据，收缩压、舒张压、年龄和脉搏波构型与未来卒中发病率相关，单纯收缩期高血压似乎与动脉僵硬度无关，易患卒中。单纯收缩期高血压的患病率随着年龄的增长和脉搏波重搏切迹的钝化程度而增加。单纯收缩期高血压患者中风的发生率是血压正常者的2-4倍。虽然舒张压与卒中发生率相关，但在收缩期高血压受试者中，舒张压分量对风险评估的贡献很小，而在该亚组的男性中，舒张压分量似乎与卒中发生率无关。
Based on prospective data from the Framingham study relating systolic pressure, diastolic pressure, age and pulse-wave configuration to future stroke incidence, it appears that isolated systolic hypertension predisposes to stroke independent of arterial rigidity. The prevalence of isolated systolic hypertension increased with age and with the degree of blunting of the dicrotic notch in the pulse wave. Subjects with isolated systolic hypertension experienced 2-4 times as many strokes as did normotensive persons. While diastolic pressure is related to stroke incidence, in the subject with systolic hypertension, the diastolic component adds little to risk assessment and in men in this subgroup, appears unrelated to stroke incidence.