Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.
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DOI：
10.1038/s41467-023-39946-9
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发表时间：
2023-07-13
影响因子：
16.6
通讯作者：
Goriounova NA
中科院分区：
文献类型：
--
作者：
Driessens SLW;Galakhova AA;Heyer DB;Pieterse IJ;Wilbers R;Mertens EJ;Waleboer F;Heistek TS;Coenen L;Meijer JR;Idema S;de Witt Hamer PC;Noske DP;de Kock CPJ;Lee BR;Smith K;Ting JT;Lein ES;Mansvelder HD;Goriounova NA
GWAS已经鉴定了许多与人类认知相关的基因，但它们在人脑中的细胞类型表达谱是未知的。这些基因与人类大脑进化中涉及的人类加速区域（HARs）重叠，可能作用于相同的生物过程。在这里，我们研究了这些基因集是否在成年人皮层神经元中表达，以及它们的表达与神经元功能和结构的关系。我们发现，这些基因集优先表达在L3锥体神经元中的颞中回（MTG）。此外，具有较高表达的神经元具有更大的总树突长度（TDL）和更快的动作电位（AP）动力学，这些特性以前与智力有关。我们确定了一个子集的基因与TDL或AP动力学与主要的突触功能和高丰度的HARs。利用人脑细胞的转录组数据，作者表明，与人类认知和大脑进化有关的基因的表达模式在特定的神经元类型中重叠，并与细胞功能和结构有关。
GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and might act on the same biological processes. Here, we investigated whether these gene sets are expressed in adult human cortical neurons, and how their expression relates to neuronal function and structure. We find that these gene sets are preferentially expressed in L3 pyramidal neurons in middle temporal gyrus (MTG). Furthermore, neurons with higher expression had larger total dendritic length (TDL) and faster action potential (AP) kinetics, properties previously linked to intelligence. We identify a subset of genes associated with TDL or AP kinetics with predominantly synaptic functions and high abundance of HARs. Using transcriptomic data from human brain cells, the authors show that the expression patterns of the genes implicated in human cognition and brain evolution overlap in specific neuron types, and relate to cellular function and structure.
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影响因子：
16.6
作者：
Jansen PR;Nagel M;Watanabe K;Wei Y;Savage JE;de Leeuw CA;van den Heuvel MP;van der Sluis S;Posthuma D
通讯作者：
Posthuma D
影响因子：
5.3
作者：
Eyal, Guy;Mansvelder, Huibert D.;Segev, Idan
通讯作者：
Segev, Idan
DOI：
10.1093/cercor/bhab349
发表时间：
2022-05-30
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
通讯作者：
--
人类新皮质扩张涉及谷氨酸能神经元多样化。
影响因子：
64.8
作者：
Berg J;Sorensen SA;Ting JT;Miller JA;Chartrand T;Buchin A;Bakken TE;Budzillo A;Dee N;Ding SL;Gouwens NW;Hodge RD;Kalmbach B;Lee C;Lee BR;Alfiler L;Baker K;Barkan E;Beller A;Berry K;Bertagnolli D;Bickley K;Bomben J;Braun T;Brouner K;Casper T;Chong P;Crichton K;Dalley R;de Frates R;Desta T;Lee SD;D'Orazi F;Dotson N;Egdorf T;Enstrom R;Farrell C;Feng D;Fong O;Furdan S;Galakhova AA;Gamlin C;Gary A;Glandon A;Goldy J;Gorham M;Goriounova NA;Gratiy S;Graybuck L;Gu H;Hadley K;Hansen N;Heistek TS;Henry AM;Heyer DB;Hill D;Hill C;Hupp M;Jarsky T;Kebede S;Keene L;Kim L;Kim MH;Kroll M;Latimer C;Levi BP;Link KE;Mallory M;Mann R;Marshall D;Maxwell M;McGraw M;McMillen D;Melief E;Mertens EJ;Mezei L;Mihut N;Mok S;Molnar G;Mukora A;Ng L;Ngo K;Nicovich PR;Nyhus J;Olah G;Oldre A;Omstead V;Ozsvar A;Park D;Peng H;Pham T;Pom CA;Potekhina L;Rajanbabu R;Ransford S;Reid D;Rimorin C;Ruiz A;Sandman D;Sulc J;Sunkin SM;Szafer A;Szemenyei V;Thomsen ER;Tieu M;Torkelson A;Trinh J;Tung H;Wakeman W;Waleboer F;Ward K;Wilbers R;Williams G;Yao Z;Yoon JG;Anastassiou C;Arkhipov A;Barzo P;Bernard A;Cobbs C;de Witt Hamer PC;Ellenbogen RG;Esposito L;Ferreira M;Gwinn RP;Hawrylycz MJ;Hof PR;Idema S;Jones AR;Keene CD;Ko AL;Murphy GJ;Ng L;Ojemann JG;Patel AP;Phillips JW;Silbergeld DL;Smith K;Tasic B;Yuste R;Segev I;de Kock CPJ;Mansvelder HD;Tamas G;Zeng H;Koch C;Lein ES
通讯作者：
Lein ES
影响因子：
5.3
作者：
Jerng HH;Pfaffinger PJ
通讯作者：
Pfaffinger PJ