Osteoanabolic Implant Materials for Orthopedic Treatment
Osteoanabolic Implant Materials for Orthopedic Treatment
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DOI：
10.1002/adhm.201600074
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发表时间：
2016-07-20
影响因子：
10
通讯作者：
Chen, Xiao-Bo
中科院分区：
文献类型：
--
作者：
Ding, Yun-Fei;Li, Rachel W.;Chen, Xiao-Bo
由于许多人口的老龄化，骨质疏松症变得越来越普遍。骨质疏松症骨比正常骨更容易骨折，目前的骨科植入材料对于骨质疏松症病例并不理想。本文报道了一种新开发的磷酸锶（SrPO 4）涂层，并将其应用于Ti-29 Nb-13 Ta-4.6Zr（wt%），TNTZ，一种具有与天然骨相当的杨氏模量的植入材料。预期SrPO 4涂层可调节成骨细胞（OB）和破骨细胞（OC）的活性，以促进骨形成。TNTZ是一种具有良好生物相容性和高生物惰性的材料，在水热条件下在浓碱性溶液中进行预处理，然后进行水热涂层生长过程，以实现具有高结合强度的完整SrPO 4表面覆盖。由于Sr离子从SrPO 4涂层的释放及其独特的表面形貌，与对照情况相比，OB细胞表现出增加的增殖和分化，而OC的细胞反应被抑制，即，裸TNTZ。该TNTZ植入物具有接近生理学的杨氏模量和功能性SrPO 4涂层，为用于治疗骨科疾病的植入式器械的设计和制造提供了新的方向。
Osteoporosis is becoming more prevalent due to the aging demographics of many populations. Osteoporotic bone is more prone to fracture than normal bone, and current orthopedic implant materials are not ideal for the osteoporotic cases. A newly developed strontium phosphate (SrPO4) coating is reported herein, and applied to Ti-29Nb-13Ta-4.6Zr (wt%), TNTZ, an implant material with a comparative Young's modulus to that of natural bone. The SrPO4 coating is anticipated to modulate the activity of osteoblast (OB) and osteoclast (OC) cells, in order to promote bone formation. TNTZ, a material with excellent biocompatibility and high bioinertness is pretreated in a concentrated alkaline solution under hydrothermal conditions, followed by a hydrothermal coating growth process to achieve complete SrPO4 surface coverage with high bonding strength. Owing to the release of Sr ions from the SrPO4 coating and its unique surface topography, OB cells demonstrate increased proliferation and differentiation, while the cellular responses of OC are suppressed, compared to the control case, i.e., bare TNTZ. This TNTZ implant with a near physiologic Young's modulus and a functional SrPO4 coating provides a new direction in the design and manufacture of implantable devices used in the management of orthopedic conditions in osteoporotic individuals.