Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren
Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren
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DOI：
10.4269/ajtmh.2003.68.186
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发表时间：
2003-02-01
影响因子：
3.3
通讯作者：
Krishnamoorthy, R
中科院分区：
文献类型：
--
作者：
Mombo, LE;Ntoumi, F;Krishnamoorthy, R
一些研究将注意力集中在宿主遗传因素与严重疟疾易感性/抗性之间的关系上。然而，关于宿主遗传因素在无症状疟疾（一种无临床症状的低级别恶性疟原虫感染）中的作用的信息缺乏。在这项研究中，我们调查了宿主（人类）遗传多态性（葡萄糖-6-磷酸脱氢酶[G6PD]、甘露糖结合凝集素[MBL]、肿瘤坏死因子α [TNFalpha]（-308）和（-238）一氧化氮合酶2 [NOS2](-954)）与158名加蓬学童无症状恶性疟原虫感染的患病率和特征之间的潜在关系。我们发现G6PD A（-）杂合雌性（74例中有18例）无症状疟疾患病率较低（38.9%对67.3%，经卡方检验P = 0.03）。TNFalpha杂合的儿童（-238）（156例中的25例）携带大量不同的感染寄生虫基因型（2.5对1.99；方差F = 3.05）。MBL、TNFalpha（-308）或NOS2多态性与无症状疟疾之间无统计学意义的相关性。将无症状型的数据与其他形式的文献数据相结合，我们得出结论，G6PD A（-）杂合雌性对所有形式的恶性疟原虫疟疾都有保护作用，而TNFalpha（- 238a）等位基因对临床疟疾具有保护作用。
Several studies have focused their attention on the relationship between host genetic factors and susceptibility/resistance to severe malaria. However, there is a paucity of information concerning the role of host genetic factors in asymptomatic malaria, a form of low-grade Plasmodium falciparum infection without clinical symptoms. We investigated in this study the potential relationship between the host (human) genetic polymorphisms (glucose-6-phosphate dehydrogenase [G6PD], mannose binding lectin [MBL], tumor necrosis factor alpha [TNFalpha](-308) and (-238) nitric oxide synthase 2 [NOS2](-954)) and the prevalence and profile of asymptornatic P. falciparum infection in 158 Gabonese schoolchildren. We found that G6PD A(-) heterozygous females (18 of 74) have a low prevalence of asymptornatic malaria (38.9% versus 67.3%; P = 0.03, by chi-square test). Children heterozygous for TNFalpha(-238) (25 of 156) carry high number of diverse infecting parasite genotypes (2.5 versus 1.99; variance F = 3.05). No statistically significant association was found between MBL, TNFalpha(-308) or NOS2 polymorphisms and asymptomatic malaria. Upon combining our data on asymptornatic forms with those from the literature for others forms, we conclude that G6PD A(-) heterozygous females are protected against all forms of P. falciparum malaria, and that the TNFalpha(-238A) allele confers protection against clinical malaria.