Urokinase-type plasminogen activator receptor (uPAR) expression is associated with T-stage and survival in urothelial carcinoma of the bladder
Urokinase-type plasminogen activator receptor (uPAR) expression is associated with T-stage and survival in urothelial carcinoma of the bladder
复制标题
DOI：
10.1016/j.urolonc.2014.12.001
复制
发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Laerum, Ole D.
中科院分区：
文献类型：
--
作者：
Dohn, Line Hammer;Illemann, Martin;Laerum, Ole D.
目的：评价尿激酶型纤溶酶原激活物受体（uPAR）的表达和定位模式，重点关注其在接受根治性膀胱癌治疗的膀胱尿路上皮肿瘤患者中的临床意义。uPAR是癌症侵袭和转移过程中组织重塑的中心分子，并且是癌症中确定的预后标志物。uPAR的表达和定位及其预后意义仅在尿路上皮膀胱neoplasia.Materials和Methods中进行了有限的研究：1988年至2005年，149例根治性膀胱癌患者的福尔马林固定石蜡包埋肿瘤组织中uPAR的表达和定位模式进行了研究。通过免疫组织化学测定uPAR表达，并评分为阴性或阳性。分别获得癌细胞、巨噬细胞和肌成纤维细胞在侵袭性前沿和肿瘤核心的单独值。结果：uPAR阳性率分别为122/137（89%）和118/149（74%），位于浸润前沿和肿瘤核心。uPAR主要在造口周围的肌成纤维细胞和巨噬细胞以及一些癌细胞中表达。uPAR阳性表达与肿瘤的T分期及分级均相关（P
Objectives: To evaluate the expression-and localization pattern of the urokinase-type plasminogen activator receptor (uPAR), focusing on its clinical implications in patients with urothelial neoplasia of the bladder treated with radical cystectomy. uPAR is a central molecule in tissue remodeling during cancer invasion and metastasis and is an established prognostic marker in cancer. The expression and localization of uPAR and its prognostic significance is only limitedly investigated in urothelial bladder neoplasia.Materials and methods: The expression-and localization pattern of uPAR was investigated in formalin-fixed paraffin-embedded tumor tissue from 149 patients treated with radical cystectomy between 1988 and 2005. uPAR expression was determined by immunohistochemistry and scored as either negative or positive. Separate values were obtained for cancer cells, macrophages, and myofibroblasts at the invasive front and tumor core, respectively. Statistical analyses were performed to evaluate the association of uPAR localization and score with clinicopathologic covariates and survival.Results: uPAR positivity was seen in 122/137 (89%) and 118/149 (74%) of the neoplasias at the invasive front and tumor core, respectively. uPAR was primarily expressed by myofibroblasts and macrophages in the surrounding stoma as well as some cancer cells. A significant association between uPAR positivity and T-stage as well as grade was found for all 3 cell types in tumor core (P